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DOI: 10.1055/s-2007-1024892
Hydroxylysine Excretion Does Not Indicate Collagen Damage with Downhill Running in Young Men
Publikationsverlauf
Publikationsdatum:
14. März 2008 (online)
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Abstract
The purpose of this study was to determine whether urinary excretion of hydroxylysine (HO-Lys) is increased following prolonged, predominantly downhill running. Such an increase would be evidence of exercise-induced collagen damage. Each often young men performed a treadmill running test to determine V̇O2peak (an approximation of V̇O2max) followed by 60 min of intermittent running on -10% slope. Total urine excreted from 48 h pre-exercise to 96h post-exercise was collected in 8-h samples for measurement of HO-Lys. In addition, both urinary 3-methylhistidine (3-MeHis) excretion and serum creatine kinase (SCK) activity were measured as indicators of muscle tissue damage. In no sampling period was post-exercise HO-Lys excretion altered compared with pre-exercise (e. g., pre-exercise: 82.2±9.6 µmol·24 h-1, mean±SE; 51.0±3.7 µmol·g creatinine-1; post-exercise: 72.9±2.0 µmol·24 h-1; 47.0±1.5 µmol·g creatinine-1). SCK activity was increased (346%) 24 h post-exercise, but not immediately, 48 h, or 72 h post-exercise. 3-MeHis excretion was not altered following exercise. There were no strong associations between HO-Lys excretion and either of the markers of muscle damage. We concluded that no evidence of exercise-induced collagen damage was provided by urinary HO-Lys excretion.
Key words
Connective tissue - 3-methylhistidine - serum creatine kinase - muscle damage - eccentric exercise