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Exp Clin Endocrinol Diabetes 2007; 115(1): 38-41
DOI: 10.1055/s-2007-948213
Article

© J. A. Barth Verlag in Georg Thieme Verlag KG · Stuttgart · New York

Association of Low-Grade Inflammation with Nephropathy in Type 2 Diabetic Patients: Role of Elevated CRP-Levels and 2 Different Gene-Polymorphisms of Proinflammatory Cytokines

H. Abrahamian 2 [*] , G. Endler 1 [*] , M. Exner 1 , H. Mauler 2 , M. Raith 1 , L. Endler 1 , H. Rumpold 1 , M. Gerdov 1 , C. Mannhalter 1 , R. Prager 2 , K. Irsigler 3 , O. F. Wagner 1
  • 1Department of Medical and Chemical Laboratory Diagnostics, University of Vienna, Medical School
  • 23rd medical department, Krankenhaus Lainz, Austria
  • 3Ludwig Boltzmann Research Institute for Metabolic Diseases, Vienna, Austria
Further Information

Publication History

Received 12.7.2005 First decision 29.5.2006

Accepted 27.6.2006

Publication Date:
07 February 2007 (online)

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Abstract

Background:Chronic inflammatory processes are thought to play a key role in the development of micro- and macrovascular complications in type 2 diabetes mellitus. An association between low -grade inflammation and type 2 diabetes has been described in some studies. We assayed the association of two frequent polymorphisms in proinflammatory cytokines: the interleukin 6 G(-174)C promoter polymorphism [IL-6G(-174)C], the exon 2 interleukin receptor antagonist insertion deletion polymorphism [IL1RA]) and serum CRP levels with the prevalence of diabetic nephropathy in patients suffering from type 2 diabetes mellitus.

Subjects and methods:A total of 141 patients with type 2 diabetes mellitus, with and without diabetic nephropathy was genotyped for the above mentioned polymorphisms: 66 with normoalbuminuria, 31 with microalbuminuria and 44 with macroalbuminuria. CRP levels were analysed by a high sensitivity - immunnephelometric assay.

Results:While a significant association be-tween macroalbuminuria and CRP could be observed (p<0,015), no associations were found between IL-6G(-174)C or IL1RA genotype and any stage of nephropathy. CRP-levels were similiar in the 3 different IL-6G(-174)C genotypes as well as in the 2 IL1RA genotypes.

Conclusions:In type 2 diabetic subjects elevated CRP levels are associated with an increased prevalence of albuminuria. The two investigated proinflammatory polymorphisms do not seem to contribute to initiation of nephropathy in type 2 diabetic patients but we cannot exclude effects of these polymorphisms on course of nephropathy.

Key words

low grade inflammation - diabetes type 2 - diabetic nephropathy - proinflammatory polymorphisms

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1 H.A. and G.E. contributed equally to the present paper

Correspondence

H. Abrahamian

City Hospital Vienna Lainz

3rd Medical Department

Wolkersbergenstrasse 1

1130 Vienna

Austria

Phone: +43(1)80110

Fax: +43(1)801102346