Subscribe to RSS
DOI: 10.1055/s-2007-963427
© Georg Thieme Verlag KG Stuttgart · New York
Ernährungsfaktoren und Ernährungstherapie beim Reizdarmsyndrom - was ist valide?
Nutritional Factors and Nutritional Therapy for Irritable Bowel Syndrome - What is Worthwhile?Publication History
Manuskript eingetroffen: 19.2.2007
Manuskript akzeptiert: 16.7.2007
Publication Date:
06 March 2008 (online)

Zusammenfassung
Die Prävalenz von Reizdarmsyndrom (RDS) hat in den letzten 50 Jahren in den Ländern mit westlichen Verzehrsgewohnheiten zugenommen, 20 - 65 % der Patienten mit Reizdarmsyndrom sehen einen Zusammenhang zwischen Nahrungsbestandteilen und der Beschwerdesymptomatik. Die Daten zu Eliminationsdiäten und Provokationsversuchen sind jedoch widersprüchlich. Obwohl es Untersuchungen gibt, dass Ballaststoffe bei einigen Reizdarmpatienten helfen können, gibt es in der Literatur keine einheitlichen diätetischen Empfehlungen. Einige Studien belegen, dass Probiotika zu einer Minderung der Symptome beitragen können. Trotz verschiedener Arbeiten, die sich mit der Thematik beschäftigen, erscheint es schwierig, Ernährungsempfehlungen für Reizdarmpatienten zu formulieren; jedoch kann eine Ernährungsberatung durchaus wertvoll für die Patienten sein. Weitere prospektive Studien sind erforderlich, um den Einfluss von diätetischen Faktoren und Probiotika in diesem Zusammenhang zu evaluieren.
Abstract
The prevalence of irritable bowel syndrome (IBS) has increased over the last 50 years in countries where a Western-style diet has been prominent or introduced and 20 - 65 % of patients with irritable bowel syndrome (IBS) attribute their symptoms to something in food that activates an abnormal response. However, data from dietary elimination and re-challenge studies are inconclusive. Although investigations have shown that bran may be helpful in some patients, a complete review of the literature does not reveal conclusive evidence that a high fibre diet therapy is effective in IBS. From the limited reports on probiotics, there appears to be a trend to decreasing symptoms. Despite numerous reviews on this subject, it is very difficult to give general dietary advice to IBS patients, but dietary experts may have a positive role in managing such patients. It is clear that much more prospective research is needed to study both dietary factors and probiotics in these areas.
Schlüsselwörter
Reizdarmsyndrom - Ernährungstherapie - Fruktosemalabsorption - Laktoseintoleranz - Diät - Prä-/Probiotika - Gluten - Pfefferminzöl
Key words
irritable bowel syndrome - nutrition therapy - fructose malabsorption - lactose malabsorption - diet - pre-/probiotics - gluten - peppermint oil
Literatur
- 1
Adam B, Liebregts T, Holtmann G.
Das Reizdarmsyndrom.
Dtsch Med Wochenschr.
2005;
130
399-401
MissingFormLabel
- 2
Aller R, de Luis D A, Izaola O. et al .
Efffects of a high-fiber diet on symptoms of irritable bowel syndrome : a randomized
clinical trial.
Nutrition.
2004;
20
735-737
MissingFormLabel
- 3
Alpers D H.
Diet and irritable bowel syndrome.
Curr Opin Gastroenterol.
2006;
22
136-139
MissingFormLabel
- 4
Arffmann S, Andersen J R, Hegnhoj J. et al .
The effect of coarse wheat bran in the irritable bowel syndrome: a double blind crossover
study.
Scand J Gastroenterol.
1985;
20
295-298
MissingFormLabel
- 5
Anderson D E, Nygren A.
Four cases of long-standing diarrhea and colic pains cured by fructose-free diet -
a pathogenetic discussion.
Acta Med Scand.
1978;
203
87-92
MissingFormLabel
- 6
Arthurs Y, Fielding J F.
Double blind trial of ispaghula poloxamer in irritable bowel syndrome.
J Assoc Physicians India.
1984;
12
1041-1044
MissingFormLabel
- 7
Au A, Gupta A, Schembri P. et al .
Rapid insertion of GLUT2 into the rat jejunal brush-border membrane promoted by glucagons-like
peptide 2.
Biochem J.
2002;
367
247-254
MissingFormLabel
- 8
Balsari A, Ceccarelli A, Dubin F. et al .
The faecal microbial population in the irritable bowel syindrome.
Microbiologica.
1982;
5
185-194
MissingFormLabel
- 9
Barbara G, Stanghellini V, Brandi G. et al .
Interactions between commensal bacteria and gut sensorimotor function in health and
disease.
Am J Gastroenterol.
2005;
100
2560-2568
MissingFormLabel
- 10
Barbara G, Stanghellini V, De Giorgio R. et al .
Activated mast cells in proximity to colonic nerves correlate with abdominal pain
in irritable bowel sindrome.
Gastroenterology.
2004;
126
693-702
MissingFormLabel
- 11
Bausserman M, Michail S.
The use of Lactobacillus GG in irritable bowel syndrome in children: a double-blind
randomized control trial.
J Pediatr.
2005;
147
197-201
MissingFormLabel
- 12
Bergonzelli G E, Blum S, Brüssow H. et al .
Probiotics as a treatment strategy for gastrointestinal diseases?.
Digestion.
2005;
72
57-68
MissingFormLabel
- 13 Böhles H, Bargon J, Stein J. Ernährungstherapie von angeborenen Stoffwechsel- und Speichererkrankungen. Stein J, Jauch KW Praxishandbuch klinische Ernährung und Infusionstherapie Springer 2003: 652-676
MissingFormLabel
- 14
Bohmer C JM, Tuynman H.
The clinical relevance of lactose malabsorption in irritable bowel syndrome.
Eur J Gastroenterol Hepatol.
1996;
8
1013-1016
MissingFormLabel
- 15
Born P, Zech J, Lehn H. et al .
Colonic bacterial activity determines the symptoms in people with fructose-malabsorption.
Hepatogastroenterology.
1995;
42
778-785
MissingFormLabel
- 16
Brigidi P, Vitali B, Swennen E. et al .
Effects of probiotic administration upon the composition and enzymatic activity of
human fecal microbiota in patients with irritable bowel syndrome or functional diarrhea.
Res Microbiol.
2001;
152
735-741
MissingFormLabel
- 17
Caldarella P, Milano A, Laterza F. et al .
Visceral sensitivity and symptoms in patients with constipation- or diarrea-predominant
irritable bowel sindrome (IBS): effect of a low-fat intraduodenal infusion.
Am J Gastroenterol.
2005;
100
383-389
MissingFormLabel
- 18
Caldarella M P, Azpiroz F, Malagelada J R.
Selective effects of nutrients on gut sensitivity and reflexes.
Gut.
2006; [Epub ahead of print];
MissingFormLabel
- 19
Camilleri M.
Management of the irritable bowel syndrome.
Gastroenterology.
2001;
120
652-668
MissingFormLabel
- 20
Camilleri M.
Probiotics and irritable bowel syndrome: rationale, putative mechanisms, and evidence
of clinical efficacy.
J Clin Gastroenterol.
2006;
40
264-269
MissingFormLabel
- 21
Cann P A, Read N W, Holdsworth C D.
What is the benefit of coarse wheat bran in patients with irritable bowel syndrome?.
Gut.
1984;
25
168-173
MissingFormLabel
- 22
Castello A, Guma A, Sevilla L. et al .
Regulation of GLUT5 gene expression in rat intestinal mucosa: regional distribution,
circadian rhythm, perinatal development an effect of diabetes.
Biochem J.
1995;
309
271-277
MissingFormLabel
- 23
Choi Y K, Johlin F C, Summers R W. et al .
Fructose intolerance: An under-recognized problem.
Am J Gastroenterol.
2003;
98
1348-1353
MissingFormLabel
- 24
Cook I J, Irvine E J, Campbell D. et al .
Effect of dietary fiber on symptoms and rectosigmoid motility in patients with irritable
bowel syndrome: a controlles crossover study.
Gastroenterology.
1990;
98
66-72
MissingFormLabel
- 25
Cummings J H, Macfarlane G T.
Gastrointestinal effects of prebiotics.
Br J Nutr.
2002;
87 (Suppl 2)
S145-S151
MissingFormLabel
- 26
Dapoigny M, Stockbrugger R W, Azpiroz F. et al .
Role of alimentation in irritable bowel syndrome.
Digestion.
2003;
67
225-233
MissingFormLabel
- 27
Dainese R, Galliani E A, DeLazzari F. et al .
Discrepancies between reported food intolerance and sensitization test findings in
irritable bowel syndrome patients.
Am J Gastroenterol.
1999;
94
1892-1897
MissingFormLabel
- 28
De Baptista G.
Nutrients and dyspepsia: paradigms and reality.
Curr Opin Nutr Metab Care.
2005;
8
562-567
MissingFormLabel
- 29
Dear K L, Elia M, Hunter J O.
Do interventions which reduce colonic bacterial fermentation improve symptoms of irritable
bowel syndrome?.
Dig Dis Sci.
2005;
50
758-766
MissingFormLabel
- 30 Dingermann T, Loew D. Magen-Darm-Erkrankungen. Dingermann T, Loew D Phytopharmakologie - Experimentelle und klinische Pharmakologie pflanzlicher Arzneimittel Stuttgart; Wissenschaftliche Verlagsgesellschaft mbH 2003: 204-213
MissingFormLabel
- 31
Drossman D A, Camilieri M, Mayer E A. et al .
AGA Technical review on irritable bowel syndrome.
Gastroenterology.
2002;
123
2108-2131
MissingFormLabel
- 32
Drossman D A.
The functional gastrointestinal disorders an the Rome III process.
Gastroenterology.
2006;
130
1377-1390
MissingFormLabel
- 33
Dyer J, Wood I S, Palejwala A. et al .
Expression of monosaccharide transporters in intestine of diabetic humans.
Am J Physiol.
2002;
282
G241-G248
MissingFormLabel
- 34
Enck P, Kremer A, Kuhlbusch R. et al .
Prevalence of lactose malabsorption among patients with functional bowel disorders.
Z Gastroenterol.
1990;
28
239-234
MissingFormLabel
- 35
Fernandez-Banares F, Esteve-Pardo M, Leon de R. et al .
Sugar malabsorption in functional bowel disease: clinical implications.
Am J Gastroenterol.
1993;
88
2044-2050
MissingFormLabel
- 36
Floch M H.
Use of Diet and Probiotic Therapy in the irritable bowel syndrome. Analysis of the
literature.
J Clin Gastroenterol.
2005;
39
S243-S246
MissingFormLabel
- 37
Fowlie S, Eastwood M, Prescott R.
Irritable bowel syndrome: assessment of psychological disturbance and its influence
on the response to fibre supplementation.
J Psychosom Res.
1992;
36
175-180
MissingFormLabel
- 38
Francis C Y, Whorwell P J.
Bran and irritable bowel syndrome: time for reappraisal.
Lancet.
1994;
344
39-40
MissingFormLabel
- 39
Freise J, Köhler S.
Peppermint oil-caraway oil fixed combination in non-ulcer dyspepsia - comparison of
the effects of enteric preparations.
Pharmazie.
1999;
54
210-215
MissingFormLabel
- 40
Gade J, Thorn P.
Paraghurt for patients with irritable bowel syndrome. A controlled clinical investigation
from general practice.
Scand J Prim Health Care.
1989;
7
23-26
MissingFormLabel
- 41
Garcia-Herrera J, Navarro M A, Marca M C. et al .
The effect of tumor necrosis factor-alpha on D-fructose intestinal transport in rabbits.
Cytokine.
2004;
25
21-30
MissingFormLabel
- 42
Gibson P R, Shepherd S J.
Personal view: food for thought - western lifestyle and susceptibility to crohn’s
disease. The FODMAP hypothesis.
Aliment Pharmacol Ther.
2005;
21
1399-1409
MissingFormLabel
- 43
Gibson P R, Newnham E, Barrett J S. et al .
Review article: fructose malabsorption and the bigger picture.
Aliment Pharmacol Ther.
2006;
25
349-363
MissingFormLabel
- 44
Goldstein R, Braverman D, Stankiewicz H.
Carbohydrate malabsorption and the effect of dietary restriction on symptoms of irritable
bowel syndrome and functional bowel complaints.
Isr Med Assoc J.
2000;
2
583-587
MissingFormLabel
- 45
Golecha A C, Chadda V S, Chadda S. et al .
Role of ispaghula husk in the management of irritable bowel syndrome (a randomized
double blind crossover Study).
J Assoc Physicians India.
1982;
30
353-355
MissingFormLabel
- 46
Gouyon F, Caillaud L, Carriere V. et al .
Simple-sugar meals target GLUT2 at enterocyte apical membranes to improve sugar absorption:
a study in GLUT2-null mice.
J Physiol.
2003;
552
823-832
MissingFormLabel
- 47
Grigoleit H G, Grigoleit P.
Peppermint oil in irritable bowel syndrome.
Phytomedicine.
2005;
12
601-606
MissingFormLabel
- 48
Grigoleit H G, Grigoleit P.
Gastrointestinal clinical pharmacology of peppermint oil.
Phytomedicine.
2005;
12
607-612
MissingFormLabel
- 49
Halpern G M, Prindiville T, Blankenburg M. et al .
Treatment of irritable bowel syndrome with Lacteol Fort: a randomized, double-blind,
cross-over trial.
Am J Gastroenterol.
1996;
91
1579-1585
MissingFormLabel
- 50
Hoekstra J H, van Kempen A A, Bijl S B. et al .
Fructose breath hydrogen tests.
Arch Dis Child.
1993;
68
136-138
MissingFormLabel
- 51
Hoekstra J H, Aker J H.
Facilitating effect of amino acids on fructose and sorbitol absorption in children.
J Pediatr Gastroenterol Nutr.
1996;
23
118-124
MissingFormLabel
- 52
Holtmann van den G, Gschossmann J M, Buenger L.
Effects of a fixed peppermint oil caraway oil combination (PCC) on symptoms and quality
of life in functional dyspepsia.
Gastroenterology.
2000;
120
(Suppl) 36
MissingFormLabel
- 53
Holtmann G.
IBS: a syndrome or many diseases?.
Best Pract Res Clin Gastroenterol.
2004;
18 (Suppl)
91-97
MissingFormLabel
- 54
Holtmeier W.
Diagnosis of celiac disease.
Z Gastroenterol.
2005;
43
1243-1252
MissingFormLabel
- 55
Hotz J, Enck P, Goebell H. et al .
: Konsensusbericht: Reizdarmsyndrom-Definition, Diagnosesicherung, Pathophysiologie
und Therapiemöglichkeiten. Konsensus der Deutschen Gesellschaft für Verdauungs- und
Stoffwechselkrankheiten.
Z Gastroenterol.
1999;
37
685-700
MissingFormLabel
- 56
Hussain Z, Quigley E M.
Systematic review: Complementary and alternative medicine in the irritable bowel syndrome.
Aliment Pharmacol Ther.
2006;
23
465-471
MissingFormLabel
- 57
Jain N K, Patel V P, Pitchumoni C S.
Sorbitol intolerance in adults. Prevalence and pathogenesis on two continents.
J Clin Gastroenterol.
1987;
9
317-319
MissingFormLabel
- 58
Jalihal A, Kurian G.
Ispaghula therapy in irritable bowel syndrome: improvement in overall well being related
to reduction in bowel dissatisfaction.
J Gastroenterol Hepatol.
1990;
5
507-513
MissingFormLabel
- 59
Johlin F C, Panther M, Kraft N.
A fructose restricted diet and dietary counselling in patients with dietary fructose
intolerance demonstrates significant reduction in symptoms and an improvement in quality
of life proportionate to the amount of fructose eliminated.
Gastroenterology.
2001;
120
A1374 (Abstract)
MissingFormLabel
- 60
Jones V A, McLaughlan P, Shorthouse M. et al .
Food intolerance: a major factor in the pathogenesis of irritable bowel syndrome.
Lancet.
1982;
20 (2)
1115-1117
MissingFormLabel
- 61
Jun D W, Lee O Y, Yoon L J. et al .
Food intolerance and skin prick test in treated and untreated irritable bowel syndrome.
World J Gastroenterol.
2006;
21
2382-2387
MissingFormLabel
- 62
Kajander K, Korpela R.
Clinical studies on alleviating the symptoms of irritable bowel syndrome.
Asia Pac J Clin Nutr.
2006;
15
576-580
MissingFormLabel
- 63
Karamanolis G, Tack J.
Nutrition and motility disorders.
Best Pract Res Clin Gastroenterol.
2006;
20
485-505
MissingFormLabel
- 64
Keller J, Franke A, Storr M. et al .
Clinically relevant breath tests in gastroenterological diagnostics - recommendations
of the German Society for Neurogastroenterology and Motility as well as the German
Society for Digestive and Metabolic Diseases.
Z Gastroenterol.
2005;
43
1071-1090
MissingFormLabel
- 65
Kellett G L, Brot-Laroche E.
Apical GLUT2. A major pathway of intestinal sugar absorption.
Diabetes.
2005;
54
3056-3062
MissingFormLabel
- 66
Kim H J, VazquezRoque M I, Camilleri M. et al .
A randomized controlled trial of a probiotic combination VSL#3 and placebo in irritable
bowel sindrome with bloating.
Neurogastroenterol Motil.
2005;
17
687-696
MissingFormLabel
- 67
Kishi K, Tanaka T, Igawa M. et al .
Sucrase-isomaltase and hexose transporter gene expressions are coordinately enhanced
by dietary fructose in rat jejunum.
J Nutr.
1999;
129
953-956
MissingFormLabel
- 68
Klauser A G, Volerholzer W A, Schindlbeck N E. et al .
Functional diagnosic work-up in patients with irritable bowel syndrome.
Z Gastroenterol.
1996;
34
273-278
MissingFormLabel
- 69
Klein-Tebbe J, Lepp U, Niggemann B. et al .
Nahrungsmittelallergie und -unverträglichkeit: Bewährte statt nicht evaluierte Diagnostik.
Deutsches Ärzteblatt.
2005;
27
A1965-A1969
MissingFormLabel
- 70
Kneepkens C M, Vonk R J, Fernandes J.
Incomplete intestinal absorption of fructose.
Arch Dis Child.
1984;
59
735-738
MissingFormLabel
- 71
Koebnick C, Wagner I, Leitzmann P. et al .
Probiotic beverage containing Lactobacillus casei Shirota improves gastrointestinal
symptoms in patients with chronic constipation.
Can J Gastroenterol.
2003;
17
655-659
MissingFormLabel
- 72
Krammer H J, Schlieger F, Harder H. et al .
Probiotics as therapeutic agents in irritable bowel syndrome.
Z Gastroenterol.
2005;
43
467-471
MissingFormLabel
- 73
Krammer H J, Kamper H, Bunau von R. et al .
Probiotic drug therapy with E. coli strain Nissle 1917 (EcN): results of a prospective
study of the records of 3,807 patients.
Z Gastroenterol.
2006;
44
651-656
MissingFormLabel
- 74
Kruis W, Weinzierl M, Schussler P. et al .
Comparison of the therapeutic effect of wheat bran, mebeverine and placebo in patients
with the irritable bowel syndrome.
Digestion.
1986;
34
196-201
MissingFormLabel
- 75
Kumar A, Kumar N, Vij J C. et al .
Optimum dosage of ispaghula husk in patients with irritable bowel syndrome: correlation
of symptom relief with whole gut transit time and stool weight.
Gut.
1987;
28
150-155
MissingFormLabel
- 76
Kurdi P, Tanaka H, van Veen H W. et al .
Cholic acid accumulation and its diminution by short-chain fatty acids in Bifidobacteria.
Microbiology.
2003;
149
2031-2037
MissingFormLabel
- 77
Ladas S D, Grammenos I, Tassios P S. et al .
Coincidental malabsorption of lactose, fructose, and sorbitol ingested at low doses
is not common in normal adults.
Dig Dis Sci.
2000;
45
2357-2362
MissingFormLabel
- 78
Lawal A, Kern M, Sidhu H. et al .
Novel evidence for hypersensitivity of visceral sensory neural circuity in irritable
bowel syndrome patients.
Gastroenterology.
2006;
130
26-33
MissingFormLabel
- 79 Layer P, Keller J. Das Reizdarmsyndrom - Pathogenese, Diagnostik und Therapie. Bremen; Uni-Med Verlag 2003: 75
MissingFormLabel
- 80
Lea R, Whorwell P J.
The Role of Food Intolerance in Irritable Bowel Syndrome.
Gastroenterol Clin N Am.
2005;
34
247-255
MissingFormLabel
- 81
Ledochowski M, Widner B, Fuchs D.
Fruktoseunverträglichkeit.
J Ernährungsmed.
2000;
3
10-14
MissingFormLabel
- 82
Ledochowski M, Murr C, Lass-Florl C. et al .
Increased serum amylase and lipase in fructose malabsorbers.
Clin Chim Acta.
2001;
311
119-123
MissingFormLabel
- 83
Lin H C.
Small intestinal bacterial overgrowth: A frame-work for understanding irritable bowel
disease.
JAMA.
2004;
292
852-858
MissingFormLabel
- 84
Locke G R, Zinsmeister A R, Talley N J. et al .
Risk factors for irritable bowel syndrome: role of analgesics and food sensitivities.
Am J Gastroenterol.
2000;
95
157-165
MissingFormLabel
- 85
Longstreth G F, Fox D D, Youkeles L. et al .
Psyllium therapy in the irritable bowel syndrome: a double blind trial.
Ann Intern Med.
1981;
95
53-56
MissingFormLabel
- 86
Longstreth G F, Thompson W G, Chey W D. et al .
Functional bowel disorders.
Gastroenterology.
2006;
130
1480-1491
MissingFormLabel
- 87
Lucey M R, Clark M L, Lowndes J O. et al .
Is bran efficacious in irritable bowel syndrome? A double blind placebo controlled
crossover study.
Gut.
1987;
28
221-225
MissingFormLabel
- 88
Madisch A, Heydenreich C J, Wieland V. et al .
Treatment of functional dyspepsia with a fixed peppermint oil and caraway oil combination
preparation as compared to cisapride. A multicenter, reference-controlled double-blind
equivalence study.
Drug Res.
1999;
49
925-932
MissingFormLabel
- 89
Madsen J L, Linnet J, Rumessen J J.
Effect of nonabsorbed amounts of a fructose-sorbitol mixture on small intestinal transit
in healthy volunteers.
Dig Dis Sci.
2006;
51
147-153
MissingFormLabel
- 90
Majamaa H, Isolauri E.
Probiotics: a novel approach in the management of food allergy.
J Allergy Clin Immunol.
1997;
99
179-185
MissingFormLabel
- 91
Malinen E, Rinttila T, Kajander K. et al .
Analysis of the fecal microbiota of irritable bowel syndrome patients and healthy
controls with real-time PCR.
Am J Gastroenterol.
2005;
100
373-382
MissingFormLabel
- 92
Manning A P, Harvey R F, Heaton K W.
Wheat fiber and irritable bowel syndrome: a controlled trial.
Lancet.
1977;
1
419-421
MissingFormLabel
- 93
Marks J, Carvou N J, Debnam E S. et al .
Diabetes increases facilitative glucose uptake and GLUT2 expression at the rat proximale
tubule brush border membrane.
J Physiol.
2003;
553
137-145
MissingFormLabel
- 94
Matthews S B, Waud J P, Roberts A G. et al .
Systemic lactose intolerance: a new perspective on an old problem.
Postgrad Med J.
2005;
81
167-173
MissingFormLabel
- 95
May B, Kuntz H D, Kieser M. et al .
Efficacy of a fixed peppermint oil and caraway oil on gastruduodenal motility.
Phytother Res.
1996;
14
20-23
MissingFormLabel
- 96
May B, Köhler S, Schneider B.
Efficacy and tolerability of a fixed combination of peppermint oil and caraway oil
in patients suffering from functional dyspepsia.
Aliment Pharmacol Ther.
2000;
14
1671-1677
MissingFormLabel
- 97
Micklefield G, Greving I, May B.
Effects of peppermint oil and caraway oil on gastrointestinal motility.
Phytother Res.
2000;
14
20-23
MissingFormLabel
- 98
Mishkin D, Sablauskas L, Yalovsky M. et al .
Fructose and sorbitol malabsorption in ambulatory patients with functional dyspepsia:
comparison with lactose maldigestion/malabsorption.
Dig Dis Sci.
1997;
42
2591-2598
MissingFormLabel
- 99
Mönnikes H, Schmidtmann M, Voort. et al .
Arzneimitteltherapie des Reizdarmsyndroms.
Internist.
2006;
47
1073-1083
MissingFormLabel
- 100
Molin C.
Probiotics in foods not containing milk or millk constituents, with special reference
to Lactobacillus plantarum 299v.
Am J Clin Nutr.
2001;
73
380S-385S
MissingFormLabel
- 101
Monsbakken K W, Vandvik P O, Farup P G.
Perceived food intolerance in subjects with irritable bowel syndrome - etiology, prevalence
and consequences.
Eur J Clin Nutr.
2006;
60
667-672
MissingFormLabel
- 102
Müller P, Meier C, Böhme H J. et al .
Fructose breath hydrogen test - is it really a harmless diagnostic procedure?.
Dig Dis.
2003;
21
276-278
MissingFormLabel
- 103
Nelis G F, Vermeeren M A, Jansen W.
Role of fructose-sorbitol malabsorption in the irritable bowel syndrome.
Gastroenterology.
1990;
99
1016-1020
MissingFormLabel
- 104
Newcomer A D, McGill D B.
Irritable bowel syndrome. Role of lactase deficiency.
Mayo Clin Proc.
1983;
58
339-341
MissingFormLabel
- 105
Niec A M, Frankum B, Talley N J.
Are adverse food reactions linked to irritable bowel syndrome?.
Am J Gastroenterol.
1998;
93
2184-2190
MissingFormLabel
- 106
Niedzielin K, Kordecki H, Birkenfeld B.
A controlled, double-blind, randomized study on the efficacy of Lactobacillus plantarum
299V in patients with irritable bowel syndrome.
Eur J Gastroenterol Hepatol.
2001;
13
1143-1147
MissingFormLabel
- 107
Nigam P, Kapoor K K, Rastog C K. et al .
Different therapeutic regimens in irritable bowel syndrome.
J Assoc Physicians India.
1984;
12
1041-1044
MissingFormLabel
- 108
Niv E, Naftali T, Hallak R. et al .
The efficacy of Lactobacillus reuteri ATCC 55 730 in the treatment of patients with
irritable bowel syndrome - a double blind, placebo-controlled, randomized study.
Clin Nutr.
2005;
24
925-931
MissingFormLabel
- 109
Nobaek S, Johansson M L, Molin G. et al .
Alteration of intestinal microflora is associated with reduction in abdominal bloating
and pain in patients with irritable bowel syndrome.
Am J Gastroenterol.
2000;
95
1231-1238
MissingFormLabel
- 110
Nucera G, Gabrielli M, Lupascu A. et al .
: Abnormal breath test to lactose, fructose and sorbitol in irritable bowel sindrome
may be explained by small intestinal bacterial overgrowth.
Aliment Pharmacol Ther.
2005;
21
1391-1395
MissingFormLabel
- 111
O’Mahony L, McCarthy J, Kelly P. et al .
Lactobacilli and bifidobacterium in irritable bowel syndrome: symptom responses and
relationship to cytokine profiles.
Gastroenterology.
2005;
128
541-551
MissingFormLabel
- 112
O’Sullivan M A, O’Morain C A.
Bacterial supplementation in the irritable bowel syndrome: a randomized double-blind
placebo-controlled crossover study.
Dig Liver Dis.
2000;
32
294-301
MissingFormLabel
- 113
Park M I, Camilleri M.
Is there a role of food allergy in irritable bowel syndrome and functional dyspepsia?
A systematic review.
Neurogastroenterol Motil.
2006;
18
595-607
MissingFormLabel
- 114
Parker T J, Woolner J T, Prevost A T. et al .
Irritable bowel syndrome: is the search for lactose intolerance justified?.
Eur J Gastroenterol Hepatol.
2001;
13
219-225
MissingFormLabel
- 115
Parisi G, Bottona E, Carrara M. et al .
Treatment effects of partially hydrolyzed guar gum on symptoms and qualità of life
of patients with irritable bowel sindrome: a multicenter randomized open trial.
Dig Dis Sci.
2005;
50
1107-1112
MissingFormLabel
- 116
Parisi G C, Zilli M, Miani M P. et al .
High-fiber diet supplementation in patients with irritable bowel sindrome (IBS): a
multicenter, randomized, open trial comparison between wheat bran diet and partially
hydrolyzed guar gum (PHGG).
Dig Dis Sci.
2002;
47
1697-1704
MissingFormLabel
- 117
Petitpierre M, Gumovski P, Girard J P.
Irritable bowel syndrome and hypersensitivity to food.
Ann Allergy.
1985;
54
538-540
MissingFormLabel
- 118
Prior A, Whorwell P J.
Double blind study of ispaghula in irritable bowel syndrome.
Gut.
1987;
28
1510-1513
MissingFormLabel
- 119
Quartero A O, Meineche-Schmidt V, Muris J. et al .
Bulking agents, antispasmodic and antidepressant medication for the treatment of irritable
bowel syndrome.
The Cochrane Database of Systematic Reviews.
2005;
Issue 2. Art. No.: CD 003 460
DOI: 0.1002 / 14 651858.CD 003 460.pub2
MissingFormLabel
- 120
Quigley E.
The use of probiotics in functional bowel disease.
Gastroenterol Clin N Ann.
2005;
34
533-545
MissingFormLabel
- 121
Ravich W J, Bayless T M, Thomas M.
Fructose. Incomplete intestinal absorption in humans.
Gastroenterology.
1983;
84
26-29
MissingFormLabel
- 122
Ritchi J A, Truelove S C.
Treatment of irritable bowel syndrome with lorazepam, hyoscine butylbromide and ispaghula
husk.
BMJ.
1979;
1
376-378
MissingFormLabel
- 123
Ritchi J A, Truelove S C.
Comparison of various treatments for irritable bowel syndrome.
BMJ.
1980;
281
1317-1319
MissingFormLabel
- 124
Riordan S M, Kim R.
Bacterial overgrowth as a cause of irritable bowel syndrome.
Curr Opin Gastroenterol.
2006;
22
669-673
MissingFormLabel
- 125
Roberfroid M B, Delzenne N M.
Dietary fructans.
Annu Rev Nutr.
1998;
18
117-143
MissingFormLabel
- 126
Romagnuolo J, Schiller D, Baily R J.
Using breath tests wisely in a gastroenterology practice: An evidence-based review
of indications and pitfalls in interpretation.
Am J Gastroenterol.
2002;
97
1113-1126
MissingFormLabel
- 127
Rumessen J J, Gudmand-Hoyer E.
Absorption capacity of fructose in healthy adults. Comparison with sucrose and its
constituent monosaccharides.
Gut.
1986;
27
1161-1168
MissingFormLabel
- 128
Rumessen J J, Gudmand-Hoyer E.
Malabsorption of fructose-sorbitol mixtures. Interactions causing abdominal distress.
Scand J Gastroenterol.
1987;
22
431-436
MissingFormLabel
- 129
Rumessen J J, Gudmand-Hoyer E.
Functional bowel disease: Malabsorption and abdominal distress after ingestion of
fructose, sorbitol, and fructose-sorbitol mixtures.
Gastroenterology.
1988;
95
694-700
MissingFormLabel
- 130
Rumessen J J.
Fructose and related food carbohydrates. Source, intake, absorption, and clinical
implications.
Scand J Gastroenterol.
1992;
27
819-828
MissingFormLabel
- 131
Saggioro A.
Probiotics in the treatment of irritable bowel syndrome.
J Clin Gastroenterol.
2004;
38 (Suppl)
S104-106. Erratum in: J Clin Gastroenterol 2005; 39: 261
MissingFormLabel
- 132
Saito Y A, Locke G R, Weaver A L. et al .
Diet and functional gastrointestinal disorders: a population-based case-control study.
Am J Gastroenterol.
2005;
100
2743-2748
MissingFormLabel
- 133
Sanders D S, Carter M J, Hurlstone D P. et al .
Association of adult coeliac disease with irritable bowel syndrome: a case-control
study in patients fulfilling ROME II criteria referred to secondary care.
Lancet.
2001;
358
1504-1508
MissingFormLabel
- 134
Schultz M, Linde H J, Lehn N. et al .
Immunomodulatory consequences of oral administration of Lactobacillus rhamnosus strain
GG in healthy volunteers.
J Dairy Res.
2003;
70
165-173
MissingFormLabel
- 135
Sen S, Mullan M M, Parker T J. et al .
: Effect of Lactobacillus plantarum 299v on colonic fermentation and symptoms of irritable
bowel syndrome.
Dig Dis Sci.
2002;
47
2615-2620
MissingFormLabel
- 136
Shahbazkhani B, Forootan M, Merat S. et al .
Coeliac disease presenting with symptoms of irritable bowel syndrome.
Aliment Pharmacol Ther.
2003;
18
231-235
MissingFormLabel
- 137
Shepherd E J, Helliwell P A, Mace O J. et al .
Stress and glucocorticoid inhibit apical GLUT2-trafficking and intestinal glucose
absorption in rat small intestine.
J Physiol.
2004;
560
281-290
MissingFormLabel
- 138
Shepherd S J, Gibson P R.
Fructose malabsorption and symptoms of irritable bowel syndrome: guidelines for effective
dietary management.
J Am Diet Assoc.
2006;
106
1631-1639
MissingFormLabel
- 139
Simren M, Mansson A, Langkilde A M. et al .
Food-related gastrointestinal symptoms in the irritable bowel syndrome.
Digestion.
2001;
63
108-115
MissingFormLabel
- 140
Skoog S M, Bharucha A E.
Dietary fructose and gastrointestinal symptoms: a review.
Am J Gastroenterol.
2004;
99
2046-2050
MissingFormLabel
- 141
Snook J, Shepherd H A.
Bran supplementation in the treatment of irritable bowel syndrome.
Aliment Pharmacol Ther.
1994;
8
511-514
MissingFormLabel
- 142
Soltoft J, Gudman-Hoyer E, Krag B. et al .
A double blind trial of the effect of wheat bran on symptoms of irritable bowel syndrome.
Lancet.
1976;
2
270-272
MissingFormLabel
- 143 Stein J, Jordan A. Ernährung bei Krankheiten des Gastrointestinaltraktes. Stein J, Jauch KW Praxishandbuch klinische Ernährung und Infusionstherapie Springer-Verlag Berlin, Heidelberg, New York 2003: 582-626
MissingFormLabel
- 144
Summers R W, Johlin F C.
Fructose intolerance is due to rapid orocecal transit and not small bowel bacterial
overgrowth.
Gastroenterology.
2001;
120
A1369 (Abstract)
MissingFormLabel
- 145
Symons P, Jones M P, Kellow J E.
Symptom provocation in irritable bowel syndrome. Effects of differing doses of fructose-sorbitol.
Scand J Gastroenterol.
1992;
27
940-944
MissingFormLabel
- 146
Terjung B, Lammert F.
Laktoseintoleranz: Neue Aspekte eines alten Problems.
Dtsch Med Wochenschr.
2007;
132
271-275
MissingFormLabel
- 147
Thiesen A, Wild G E, Keelan M. et al .
Locally and systemically active glucocorticosteroids modify intestinal absorption
of sugars in rats.
J Appl Physiol.
2003;
94
583-590
MissingFormLabel
- 148
Tolliver B A, Jackson M S, Jackson K L. et al .
Does lactose maldigestion really play a role in the irritable bowel?.
J Clin Gastroenterol.
1996;
23
15-17
MissingFormLabel
- 149
Torii A, Toda G.
Management of Irritable Bowel Syndrome.
Int Med.
2004;
43
353-359
MissingFormLabel
- 150
Toskes P P, Connery K L, Ritchey T W.
Calcium oplycarbophil compared with placebo in the irritable bowel syndrome.
Aliment Pharmacol Ther.
1993;
7
87-92
MissingFormLabel
- 151
Truswell A S, Seach J M, Thorburn A W.
Incomplete absorption of pure fructose in healthy subjects and the facilitating effect
of glucose.
Am J Clin Nutr.
1988;
48
1424-1430
MissingFormLabel
- 152
Vanderhoof J A, Young R J.
Use of prebiotics in childhood gastrointestinal disorders.
J Pediatr Gastroenterol Nutr.
1998;
27
323-332
MissingFormLabel
- 153
Verdu E F, Collins S M.
Irritable bowel syndrome and probiotics: from rationale to clinical use.
Curr Opin Gastroenterol.
2005;
21
697-701
MissingFormLabel
- 154
Vernia P, Marinaro V, Argnani F. et al .
Self-reported milk intolerance in irritable bowel syndrome: what should we believe?.
Clin Nutr.
2004;
23
996-1000
MissingFormLabel
- 155
Vesa T H, Seppo L M, Marteau P R. et al .
Role of irritable bowel syndrome in subjective lactose intolerance.
Am J Clin Nutr.
1998;
67
71 071-71 075
MissingFormLabel
- 156
Villagrasa M, Boix J, Humbert P. et al .
Aleatory clinical study comparing otilonium bromide with a fiber-rich diet in the
treatment of irritable bowel syndrome.
Ital J Gastroenterol.
1991;
23 (Suppl)
67-70
MissingFormLabel
- 157
Wahnschaffe U, Ullrich R, Riecken E O. et al .
Celiac disease-like abnormalities in a subgroup of patients with irritable bowel syndrome.
Gastroenterology.
2001;
121
1329-1338
MissingFormLabel
- 158
Walker J, Jijon H B, Diaz H. et al .
5-Aminoimidazole-4-carboxamide riboside (AICAR) enhances GLUT2-dependent jejunal glucose
transport: a possible role for AMPK.
Biochem J.
2005;
385
485-491
MissingFormLabel
- 159
Zar S, Kumar D, Benson M J.
Food hypersensitivity and irritable bowel syndrome.
Aliment Pharmacol Ther.
2001;
15
439-449
MissingFormLabel
- 160
Zar S, Benson M J, Kumar D.
Food-specific serum IgG4 and IgE titers to common food antigens in irritable bowel
syndrome.
Am J Gastroenterol.
2005;
100
1550-1557
MissingFormLabel
- 161
Zuckerman M J.
The role of fiber in the treatment of irritable bowel syndrome.
J Clin Gastroenterol.
2006;
40
104-108
MissingFormLabel
Prof. Jürgen M. Stein
Katharina-Kasper-Kliniken
Ginnheimer Straße 3-5
60487 Frankfurt
Phone: ++ 49/69/79 39 21 19
Fax: ++ 49/69/79 39 26 6
Email: j.stein@em.uni-frankfurt.de