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Int J Sports Med 2007; 28(9): 798-803
DOI: 10.1055/s-2007-964914
Immunology

© Georg Thieme Verlag KG Stuttgart · New York

Modulation of Dendritic Cells by Endurance Training

L.-M. Chiang1 , Y.-J. Chen2 , J. Chiang1 , L.-Y. Lai3 , Y.-Y. Chen4 , H.-F. Liao5
  • 1Graduate Institute of Sport Coaching Science, Chinese Culture University, Taipei, Taiwan - Republic of China
  • 2Department of Radiation Oncology, Mackay Memorial Hospital, Taipei, Taiwan - Republic of China
  • 3Department of Physical Education, Chinese Culture University, Taiwan, Taiwan - Republic of China
  • 4Department of Physical Education, National Taiwan College of Physical Education, Taichung, Taiwan - Republic of China
  • 5Department of Molecular Biology and Biochemistry, National Chiayi University, Chiayi, Taiwan - Republic of China
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Publikationsverlauf

accepted after revision August 4, 2006

Publikationsdatum:
13. April 2007 (online)

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Abstract

A periodized endurance training is able to adapt physical and psychological needs and increase exercise performance. Dendritic cells (DCs) play a key role in regulation of the immune response. In the present study, we trained Sprague-Dawley (SD) rats for five weeks using a progressive endurance protocol with the aim of measuring the effect on myeloid DC differentiation and maturation. Rats were divided into a non-exercise group (NEG) and an exercise group (EG). Bone marrow cells were isolated from these rats after training and cultured in the presence of granulocyte/monocyte-colony stimulatory factor (GM‐CSF) and interleukin (IL)-4, and the resultant immature DCs were triggered with lipopolysaccharide to mature. DCs were collected and the main characteristics of DCs were assessed. The recovery rate and the expression of major histocompatibility complex (MHC) class II molecules for DC collected from EG was markedly greater than NEG. The function of DCs from EG to trigger a mixed leukocyte reaction and IL-12 production was higher than NEG. There was no liver and renal toxicity observed in all rats. Changes in food/water consumption and body weight increase between the groups were normal for the conditions. This study demonstrated that periodized endurance training is able to modulate DC development and shift them towards a more mature state.

Key words

periodized endurance training - dendritic cell (DC) - immune function

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Dr. Hui-Fen Liao

Department of Molecular Biology and Biochemistry
National Chiayi University

300 University Road

Chiayi 600

Taiwan - Republic of China

eMail: liaohf@seed.net.tw