Effect of NSAID on Muscle Injury and Oxidative Stress

S. McAnulty; L. McAnulty; D. Nieman; J. Morrow; C. Dumke; D. Henson

doi:10.1055/s-2007-964966

International Journal of Sports Medicine, Inhaltsverzeichnis

Int J Sports Med 2007; 28(11): 909-915
DOI: 10.1055/s-2007-964966

Physiology & Biochemistry

Effect of NSAID on Muscle Injury and Oxidative Stress

S. McAnulty¹ , L. McAnulty² , D. Nieman¹ , J. Morrow³ , C. Dumke¹ , D. Henson⁴

¹Health, Leisure, and Exercise Science, Appalachian State University, Boone, NC, USA
²Family and Consumer Sciences, Appalachian State University, Boone, NC, USA
³Department of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA
⁴Department of Biology, Appalachian State University, Boone, NC, USA

Abstract

Indirect markers of muscle damage and delayed onset muscle soreness were examined and correlated to changes in oxidative stress, plasma antioxidant potential, and use or nonuse of non-steroidal anti-inflammatory drugs in 60 ultra-marathoners following the Western States Endurance Run. Blood was collected prior to and immediately following the race and analyzed for muscle damage by creatine phosphokinase and oxidative stress by F₂-isoprostanes, protein carbonyls, and lipid hydroperoxides and antioxidant potential by the ferric reducing ability of plasma. Subjects recorded delayed onset muscle soreness during the week following the race. Lipid hydroperoxide concentrations were unchanged, but F₂-isoprostanes, protein carbonyls, ferric reducing ability of plasma, creatine phosphokinase, and delayed onset muscle soreness increased significantly postrace. Protein carbonyls were significantly higher postrace in nonsteroidal anti-inflammatory drug users versus nonusers (p < 0.05). However, there was no difference between users and non-users for all other markers. Postrace creatine phosphokinase concentrations were not correlated with oxidative stress markers but were correlated with changes in delayed onset muscle soreness. Based upon these findings, caution should be used when consuming nonsteroidal anti-inflammatory drugs during ultra distance events.

Key words

exercise - drugs - antioxidant potential - lipid oxidation - protein oxidation

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References

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