Oral Contraceptive Phase Has no Effect on Endurance Test

Abstract

Thirteen female cyclists/triathletes (mean peak V·O₂ = 53.0 + 5.6 ml · kg^-1 · min^-1) using a monophasic oral contraceptive (OC) performed an endurance test (1-h cycle) at three time points of an OC cycle. Testing times were during the OC consumption phase (CONS), early in the OC withdrawal phase (WITH1) and late in the OC withdrawal phase (WITH2). Resting endogenous serum oestradiol and progesterone concentrations were measured. Power output, heart rate (HR), ventilation (V·_E), oxygen consumption (V·O₂), respiratory exchange ratio (RER), rating of perceived exertion (RPE), blood lactate and blood glucose were measured throughout the 1-h test. Serum oestradiol levels were greater during WITH2 compared to the CONS (p < 0.05). No significant differences were present between the testing times for mean power output (172 - 173 watts), HR (163 - 166 bpm), V·O₂ (41.3 - 41.7 mL · kg^-1 · min^-1), RER (0.93 - 0.94), RPE (14.5 - 14.8) and blood glucose concentration (5.3 - 5.5 mmol · L^-1) (p > 0.05). Greater mean V·_E (by 3.4 and 5.7 L · min^-1) and V·E/V·O₂ (by 1.0 and 2.0) values were measured during CONS compared to WITH1 and WITH2 respectively and blood lactate values (by 1.2 mmol · L^-1) compared to WITH1 only (p < 0.05). Despite variation in some physiological variables, there was no difference in endurance performance throughout an OC cycle in endurance trained female athletes.

menstrual cycle - cycling - ventilation - lactate - oxygen consumption

References

• 1 Bemben D A, Boileau R A, Bahr J M, Nelson R A, Misner J E. Effects of oral contraceptives on hormonal and metabolic responses during exercise.  Med Sci Sports Exerc. 1992;  24 434-441
• 2 Bemben D A, Salm P C, Salm A J. Ventilatory and blood lactate responses to maximal treadmill exercise during the menstrual cycle.  J Sports Med Phys Fitness. 1995;  35 257-262
• 3 Bernades R P, Radomski M W. Growth hormone responses to continuous and intermittent exercise in females under oral contraceptive therapy.  Eur J Appl Physiol. 1998;  79 24-29
• 4 Bishop D. Reliability of a 1-h endurance performance test in trained female cyclists.  Med Sci Sports Exerc. 1997;  29 554-559
• 5 Bonen A, Haynes F W, Graham T E. Substrate and hormonal responses to exercise in women using oral contraceptives.  J Appl Physiol. 1991;  70 1917-1927
• 6 Borg G. Physical Performance and Perceived Exertion. Lundi, Sweden; Gleerup 1962: pp.64
• 7 Bryner R W, Toffle R C, Ullrich I H, Yeater R A. Effect of low dose oral contraceptives on exercise performance.  Br J Sports Med. 1996;  30 36-40
• 8 Brynhildsen J, Lennartsson H, Klemetz M, Dahlquist P, Hedin B, Hammar M. Oral contraceptive use among female elite athletes and age-matched controls and its relation to low back pain.  Acta Obstet Gynecol Scand. 1997;  76 873-878
• 9 Casazza G A, Jacobs K A, Suh S-H, Miller B F, Horning M A, Brooks G A. Menstrual cycle phase and oral contraceptive effects on triglyceride mobilization during exercise.  J Appl Physiol. 2004;  97 302-309
• 10 Casazza G A, Suh S-H, Miller B F, Navazio F M, Brooks G A. Effects of oral contraceptives on peak exercise capacity.  J Appl Physiol. 2002;  93 1698-1702
• 11 D'Eon T MD, Sharoff C, Chipkin S R, Grow D, Ruby B C, Braun B. Regulation of exercise carbohydrate metabolism by estrogen and progesterone in women.  Am J Physiol. 2002;  283 E1046-E1055
• 12 England S E, Fahri L E. Fluctuations in alveolar CO₂ and in base excess during the menstrual cycle.  Respirat Physiol. 1976;  26 157-161
• 13 Fotherby K. Bioavailability of orally administered sex steroids used in oral contraception and hormone replacement therapy.  Contraception. 1996;  54 59-69
• 14 Grucza R, Pekkarinen H, Hanninen O. Cardiorespiratory responses to bicycle incremental exercise in women taking oral contraceptives.  Biol Sport. 2002;  19 267-279
• 15 Jacobs K A, Casazza G A, Suh S-H, Horning M A, Brooks G A. Fatty acid reesterification but not oxidation is increased by oral contraceptive use in women.  J Appl Physiol. 2005;  1720-1731
• 16 Janse de Jonge X AK. Effects of the menstrual cycle on exercise performance.  J Sports Med. 2003;  33 833-851
• 17 Lebrun C M. Effect of the different phases of the menstrual cycle and oral contraceptives on athletic performance.  Sports Med. 1993;  16 400-430
• 18 Lebrun C M, Petit M A, McKenzie D C, Taunton J E, Prior J C. Decreased maximal aerobic capacity with use of a triphasic oral contraceptive in highly active women: a randomised controlled trial.  Br J Sports Med. 2003;  37 315-320
• 19 Lynch N J, De Vito G, Nimmo M A. Low dosage monophasic oral contraceptive use and intermittent exercise performance and metabolism in humans.  Eur J Appl Physiol. 2001;  84 296-301
• 20 McNeill A W, Mozingo E. Changes in the metabolic cost of standardized work associated with the use of an oral contraceptive.  J Sports Med. 1981;  21 238-244
• 21 Norton K, Olds T. Anthropometrica. Sydney; University of New South Wales Press 1996: 33-52
• 22 Redman L M, Hamdorf P, Norman R J, Westlander G, Scroop G C. The menstrual cycle or oral contraceptive pill: can it benefit or hinder exercise in women?.  Med Sci Sports Exerc. 2004;  36 S280
• 23 Schoene R B, Robertson H T, Pierson D J, Peterson A P. Respiratory drives and exercise in menstrual cycles of athletic and nonathletic women.  J Appl Physiol. 1981;  50 1300-1305
• 24 Suh S-H, Casazza G A, Horning M A, Miller B F, Brooks G A. Effects of oral contraceptives on glucose flux and substrate oxidation rates during rest and exercise.  J Appl Physiol. 2003;  94 285-294
• 25 Williams T J, Krahenbuhl G S. Menstrual cycle phase and running economy.  Med Sci Sports Exerc. 1997;  29 1609-1618