Thorac Cardiovasc Surg 2007; 55(8): 505-508
DOI: 10.1055/s-2007-965645
Original Thoracic

© Georg Thieme Verlag KG Stuttgart · New York

Operative Indications for Lung Cancer with Idiopathic Pulmonary Fibrosis

K. Kushibe1 , T. Kawaguchi1 , M. Takahama1 , M. Kimura1 , T. Tojo1 , S. Taniguchi1
  • 1Thoracic and Cardiovascular Surgery, Nara Medical University School of Medicine, Kashihara, Japan
Further Information

Publication History

received April 18, 2007

Publication Date:
19 November 2007 (online)

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Abstract

Background: Idiopathic pulmonary fibrosis (IPF) is well known to be associated with lung cancer. However, surgical morbidity and mortality in lung cancer patients with IPF remains unclear. Methods: The data of patients who underwent surgery for non-small cell lung cancer were retrospectively reviewed. Results: Of the 1063 patients with lung cancer, 33 (3.1 %) had IPF. Patients with IPF had significantly higher postoperative pulmonary morbidity and mortality than those without IPF (33.3 vs. 2.0 %; 18.2 vs. 1.3 %, respectively, p < 0.0001). Patients with IPF had a significantly higher incidence of postoperative acute lung injury/acute respiratory distress syndrome (ALI/ARDS) than those without IPF (27.3 vs. 1.3 %, p < 0.0001). IPF patients with postoperative ALI/ARDS had a significantly lower preoperative %FVC than those without postoperative ALI/ARDS (74 ± 9 vs. 103 ± 14 %, p < 0.0001). Conclusions: Lung cancer patients with IPF who have a low preoperative %FVC should be carefully assessed prior to any surgical intervention.