A Simple and Efficient One-Pot Synthesis of 2-Substituted Benzimidazoles

Kiumars Bahrami; Mohammad Mehdi Khodaei; Iman Kavianinia

doi:10.1055/s-2007-965878

PAPER

A Simple and Efficient One-Pot Synthesis of 2-Substituted Benzimidazoles

Kiumars Bahrami*, Mohammad Mehdi Khodaei*, Iman Kavianinia
Department of Chemistry, Razi University, Kermanshah 67149, Iran
Fax: +98(831)4274559; e-Mail: k2005bahrami@yahoo.com; e-Mail: mmkhoda@razi.ac.ir;

Abstract

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Abstract

A simple and efficient procedure for the synthesis of substituted benzimidazoles through a one-pot condensation of o-phenylenediamines with aryl aldehydes in the presence of H₂O₂/HCl system in acetonitrile at room temperature is described. Short reaction time, large-scale synthesis, easy and quick isolation of the products, and excellent yields are the main advantages of this procedure.

Key words

o-phenylenediamines - benzimidazoles - aryl aldehydes - hydrogen peroxide

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Referenzen

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