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Synthesis 2007(3): 447-451
DOI: 10.1055/s-2007-965884
DOI: 10.1055/s-2007-965884
PAPER
© Georg Thieme Verlag Stuttgart · New YorkRegioselective Cross-Coupling of 1-Vinylpyrroles with Acylbromoacetylenes on Al2O3: Synthesis of 2-(2-Acylethynyl)-1-vinylpyrroles
Weitere Informationen
Received
24 July 2006
Publikationsdatum:
12. Januar 2007 (online)
Publikationsverlauf
Publikationsdatum:
12. Januar 2007 (online)
Abstract
1-Vinyl- and 1-isopropenylpyrroles enter readily (ambient temperature) into cross-coupling reaction with acylbromoacetylenes on Al2O3 to furnish regioselectively 2-(2-acylethynyl)-1-vinyl- and 2-(2-acylethynyl)-1-isopropenylpyrroles in 39-70% yield.
Key words
1-vinylpyrroles - 1-isopropenylpyrroles - acylbromoacetylenes - 2-(2-acylethynyl)pyrroles - cross-coupling reaction - Al2O3
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