Facile One-Step Synthesis of Mono-2-(p-Tolylsulfonyl)-β-cyclodextrin under Aqueous Conditions

Abstract

A new and convenient method is presented for the synthesis of mono-2-(p-tolylsulfonyl)-β-cyclodextrin under aqueous conditions that does not require large amounts of polar organic solvents such as DMF, metal-containing reagents such as dibutyltin oxide, or flammable bases such as NaH. Yields are typically around 20%.

Key words

cyclodextrins - sulfonates - regioselectivity - host-guest systems

References

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11

The response factor of the RI detector for both compounds was determined independently and is close to 1.