3-Substituted Phthalic Acid Derivatives by Sonogashira Coupling Reaction

Abstract

Phthalic acid derivatives with carbon substituents in position 3 are easily accessible by Sonogashira coupling reaction of the corresponding bromo derivative. For reasonable conversions the phthaloyl moiety is masked as the N-phenylphthalimide, which can smoothly be converted into other phthalic acid derivatives.

Key words

alkynes - palladium - cross-coupling - heterocycles - phthalic­ acid

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