A Short Synthesis of (S)-Pyrrolam A via Domino Oxidation-Wittig Reaction

Mahesh S. Majik; Jyoti Shet; Santosh G. Tilve; P. S. Parameswaran

doi:10.1055/s-2007-965920

SHORTPAPER

A Short Synthesis of (S)-Pyrrolam A via Domino Oxidation-Wittig Reaction

Mahesh S. Majik^a, Jyoti Shet^a, Santosh G. Tilve*^a, P. S. Parameswaran^b
^a Department of Chemistry, Goa University, Taleigao Plateau, Goa 403206, India
^b Chemical Oceanography Division, National Institute of Oceanography (CSIR), Dona-Paula-Goa 403004, India
Fax: +91(832)245184; e-Mail: santoshtilve@yahoo.com;

Abstract

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Abstract

A short synthesis of (S)-pyrrolam A starting from readily available N-(benzyloxycarbonyl)-l-prolinol is described that makes use of a domino primary alcohol oxidation-Wittig reaction as the key step.

Keywords

domino reaction - oxidation - Wittig reaction - asymmetric synthesis - bicyclic compounds

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References

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