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Synthesis 2007(8): 1272-1278
DOI: 10.1055/s-2007-965941
DOI: 10.1055/s-2007-965941
PSP
© Georg Thieme Verlag Stuttgart · New York
Preparation of Tertiary Amines via the Oxidative Coupling of Polyfunctional Aryl and Heteroaryl Amidocuprates
Further Information
Received
11 December 2006
Publication Date:
20 February 2007 (online)
Publication History
Publication Date:
20 February 2007 (online)
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Abstract
Highly functionalized tertiary amines can be prepared by the oxidative coupling of polyfunctional lithium amidocuprates using chloranil as an oxidant. A high functional group tolerance and insensibility to steric hindrance characterize this general amination reaction. Herein, we report a practical procedure for the preparation of aryl and heteroaryl tertiary amines.
Key words
amination - amidocuprates - C-N bond formation - lithium amides - polyfunctional Grignard reagents
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