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Synthesis 2007(6): 845-852  
DOI: 10.1055/s-2007-965942
PAPER
© Georg Thieme Verlag Stuttgart · New York

Synthesis of a Protected δ-Glyco-amino Acid Building Block for Incorporation into Peptide Chains

George Paloumbisa, Christos C. Petroua, Berthold Nockb, Theodosia Mainab, George Pairasa, Petros G. Tsoungasc, Paul Cordopatis*a
a Department of Pharmacy, University of Patras, 26504 Patras, Greece
Fax: +30(2610)997714; e-Mail: pacord@upatras.gr;
b Institute of Radioisotopes - Radiodiagnostic Products, National Centre for Scientific Research ‘Demokritos’, Agia Paraskevi Attikis, 15310 Athens, Greece
c Ministry of Development, Department of Research and Technology, 14-18 Messogion Ave, 11510 Athens, Greece
Further Information

Publication History

Received 11 October 2006
Publication Date:
20 February 2007 (online)

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Abstract

The synthesis of a suitably protected sugar amino acid (δ-glyco-amino acid) as a building block to be incorporated into the peptide chain (N-terminus) of bioactive peptide analogues is described. Its efficient coupling reactions with pilot amino acids as well as dipeptides have been accomplished by standard peptide chemistry.

Key words

carbohydrates - δ-glyco-amino acid - glycosylation - glycopeptides - radiolabelling

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