TBAB-Promoted Ligand-Free Copper-Catalyzed Cross-Coupling Reactions of Aryl Halides with Arylboronic Acids

Jin-Heng Li; Ji-Lan Li; Ye-Xiang Xie

doi:10.1055/s-2007-965958

PAPER

TBAB-Promoted Ligand-Free Copper-Catalyzed Cross-Coupling Reactions of Aryl Halides with Arylboronic Acids

Jin-Heng Li*, Ji-Lan Li, Ye-Xiang Xie
Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research (Ministry of Education), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, P. R. of China
Fax: +86(731)8872531; e-Mail: jhli@hunnu.edu.cn;

Abstract

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Abstract

Tetrabutylammonium bromide (TBAB) was found to improve the ligand-free copper-catalyzed cross-couplings of aryl halides with arylboronic acids. In the presence of 10 mol% of CuI and 20 mol% of TBAB, a variety of aryl halides underwent the coupling with arylboronic acids smoothly to afford the corresponding products in moderate to good yields.

Key words

tetrabutylammonium bromide - copper(I) iodide - aryl halide - arylboronic acid - Suzuki-Miyaura cross-coupling reaction

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