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Synthesis 2007(7): 981-983
DOI: 10.1055/s-2007-965978
DOI: 10.1055/s-2007-965978
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York
A Microwave-Assisted Alternative Synthesis of 8-Amino-2-methyl-3,4-dihydroisoquinolin-1-one
Weitere Informationen
Received
29 November 2006
Publikationsdatum:
12. März 2007 (online)
Publikationsverlauf
Publikationsdatum:
12. März 2007 (online)
![](https://www.thieme-connect.de/media/synthesis/200707/lookinside/thumbnails/10.1055-s-2007-965978-1.jpg)
Abstract
A shorter, alternative synthesis of 8-amino-2-methyl-3,4-dihydroisoquinolin-1-one is described in 32% overall yield, over three steps starting from commercially available 2-methyl-6-nitrobenzonitrile. The synthesis includes two ‘one-pot’ procedures in which the key process involves the microwave-assisted hydrolysis of a nitrile group followed by lactamization under elevated temperatures.
Key words
lactam - microwaves - cyclization - Bredereck’s reagent - isoquinolinone
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