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Synthesis 2007(8): 1214-1224
DOI: 10.1055/s-2007-966003
DOI: 10.1055/s-2007-966003
PAPER
© Georg Thieme Verlag Stuttgart · New York
Chlorotrimethylsilane-Mediated Friedländer Synthesis of Polysubstituted Quinolines
Further Information
Received
12 December 2006
Publication Date:
28 March 2007 (online)
Publication History
Publication Date:
28 March 2007 (online)
![](https://www.thieme-connect.de/media/synthesis/200708/lookinside/thumbnails/10.1055-s-2007-966003-1.jpg)
Abstract
New convenient conditions for the Friedländer synthesis of quinolines are described. Polysubstituted quinolines were readily prepared using chlorotrimethylsilane as a promoter and water-acceptor agent.
Key words
quinolines - annulation - o-amino aromatic carbonyls - chlorotrimethylsilane - parallel synthesis
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