Synthesis 2007(8): 1214-1224  
DOI: 10.1055/s-2007-966003
PAPER
© Georg Thieme Verlag Stuttgart · New York

Chlorotrimethylsilane-Mediated Friedländer Synthesis of Polysubstituted Quinolines

Sergey V. Ryabukhina,b, Dmitriy M. Volochnyuk*a,c, Andrey S. Plaskonb, Vasiliy S. Naumchika, Andrei A. Tolmachevb
a Enamine Ltd., 23 A. Matrosova st., 01103 Kyiv, Ukraine
b National Taras Shevchenko University, 62 Volodymyrska st., 01033 Kyiv-33, Ukraine
c Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Murmanska 5, 02094 Kyiv-94, Ukraine
Fax: +380(44)5373253; e-Mail: D.Volochnyuk@enamine.net;
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Publikationsverlauf

Received 12 December 2006
Publikationsdatum:
28. März 2007 (online)

Abstract

New convenient conditions for the Friedländer synthesis of quinolines are described. Polysubstituted quinolines were readily prepared using chlorotrimethylsilane as a promoter and water-acceptor agent.

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