Novel and Efficient Cyanofluoromethylation Promoted by Samarium(II) Species

Yusuke Asano; Shoko Suzuki; Tadashi Aoyama; Kosuke Shimizu; Masatsugu Kajitani; Yasuo Yokoyama

doi:10.1055/s-2007-966006

PAPER

Novel and Efficient Cyanofluoromethylation Promoted by Samarium(II) Species

Yusuke Asano^a, Shoko Suzuki^b, Tadashi Aoyama^c, Kosuke Shimizu^a, Masatsugu Kajitani^a, Yasuo Yokoyama*^a
^a Department of Chemistry, Faculty of Science and Technology, Sophia University, 7-1 Kioicho, Chiyoda-ku, Tokyo 102-8554, Japan
Fax: +81(3)32383361; e-Mail: yasuo-y@sophia.ac.jp;
^b National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki 305-8565, Japan
^c Department of Materials and Applied Chemistry, College of Science and Technology, Nihon University, 1-8-14 Kanda Surugadai, Chiyoda-ku, Tokyo 101-8308, Japan

Abstract

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Abstract

Two types of cyanofluoromethylation using a combination of samarium(II) species and chlorofluoroacetonitrile combination has been developed. One is a samarium(II) dibromide promoted reaction at low temperature, whereas the second synthetic method uses samarium(II) diiodide. These reactions proceeded smoothly to give the desired products in good to excellent yields.

Key words

cyanofluoromethylation - samarium(II) dibromide - samarium(II) diiodide - cyanohydrin - aldehyde

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Referenzen

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