Facile Synthesis of Unsymmetrical 1,n′-Disubstituted Ferrocenoyl Amino Acid Derivatives by Palladium-Catalyzed Aminocarbonylation

Árpád Kuik; Rita Skoda-Földes; László Jánosi; László Kollár

doi:10.1055/s-2007-966036

SHORTPAPER

Facile Synthesis of Unsymmetrical 1,n′-Disubstituted Ferrocenoyl Amino Acid Derivatives by Palladium-Catalyzed Aminocarbonylation

Árpád Kuik^a, Rita Skoda-Földes*^a, László Jánosi^b, László Kollár^b
^a University of Pannonia, Institute of Chemistry, Department of Organic Chemistry, P.O. Box 158, 8201 Veszprém, Hungary
^b University of Pécs, Department of Inorganic Chemistry and Research Group for Chemical Sensors of the Hungarian Academy of Sciences, P.O. Box 266, 7624 Pécs, Hungary
Fax: +36(88)624469; e-Mail: skodane@almos.vein.hu;

Abstract

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Abstract

Various unsymmetrical 1,n′-disubstituted ferrocenoyl amino acids were obtained by palladium-catalyzed aminocarbonylation starting from 1,1′-diiodoferrocene. The reactions were carried out in one-pot, using an equimolar mixture of two amino acid esters as nucleophiles. The structures of the products were determined by ¹H NMR, ¹³C NMR, IR and MS analyses. Each was found to adopt an ordered, intramolecularly hydrogen bonded conformation.

Key words

ferrocene - amino acids - carbonylations - palladium - homogeneous catalysis

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References

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