A New Chemoselective Synthesis of Brombuterol

Marcelo S. Nery; Mariangela S. Azevedo; Jari N. Cardoso; Glaucia B. C. Slana; Rosangela S. C. Lopes; Cláudio C. Lopes

doi:10.1055/s-2007-966044

PAPER

A New Chemoselective Synthesis of Brombuterol

Marcelo S. Nery, Mariangela S. Azevedo, Jari N. Cardoso, Glaucia B. C. Slana, Rosangela S. C. Lopes*, Cláudio C. Lopes*
Departamento de Química Analítica, Instituto de Química, Universidade Federal do Rio de Janeiro, CT, Bloco A, 5o andar, Rio de Janeiro, RJ, CEP 21949 900, Brazil
Fax: +55(21)25627854; e-Mail: claudiosabbatini@uol.com.br;

Abstract

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Abstract

A practical method for the synthesis of brombuterol [1-(4-amino-3,5-dibromophenyl)-2-(tert-butylamino)ethanol] in high overall yield is described starting from 4′-aminoacetophenone using a new chemoselective route.

Key words

β-agonists - chemoselective - bromination - brombuterol - clembuterol

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