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Synthesis 2007(10): 1475-1480
DOI: 10.1055/s-2007-966047
DOI: 10.1055/s-2007-966047
PAPER
© Georg Thieme Verlag Stuttgart · New York
New Synthons for the Preparation of Arylimidazolines and Tetrahydropyrimidine Analogues
Further Information
Received
15 December 2006
Publication Date:
02 May 2007 (online)
Publication History
Publication Date:
02 May 2007 (online)
Abstract
An adaptation of the Fujioka method for the efficient synthesis of arylimidazolines from aryl aldehydes was used for the synthesis of aryltetrahydropyrimidines. tert-Butoxycarbonyl-protected bromo- or iodophenyl-substituted imidazolines and tetrahydropyrimidines both undergo Suzuki coupling reactions with arylboronic acids in good yields.
Key words
imidazolines - tetrahydropyrimidines - protecting groups - Suzuki coupling - amidine heterocycles
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