Abstract
A short and flexible route for the synthesis of 1,2-diisopropyl-3-methyl-(3S ,4R ,5R )-4,5-dihydroxyhexahydro-1,2,3-pyridazinetricarboxylate, from readily available acrolein, is described. This approach involves an asymmetric α-hydrazination, dihydroxylation and intramolecular cyclisation as key steps.
Key words
piperazic acid -
l -proline - α-hydrazination - dihydroxylation - intramolecular cyclisation
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