Kernaussagen
Epidemiologie
Risikofaktoren und Früherkennung
Therapie
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Die potenziell kurativen Therapieoptionen mit guter Prognose - wie chirurgische Resektion, Lebertransplantation und lokal ablative Therapie wie RFTA, PEI und TACE - stehen für den überwiegenden Teil der Patienten, bei denen die Erkrankung erst in einem fortgeschrittenen Stadium diagnostiziert wird, nicht mehr zur Verfügung.
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Unter einem palliativen Aspekt kann bei nicht zu großem Tumor, fehlenden Hinweisen für eine Gefäßinvasion sowie guter Leberfunktion die TACE lebensverlängernd wirken.
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Darüber hinaus gibt es für Patienten mit lokal fortgeschrittenem, multifokalem oder metastasiertem HCC trotz zahlreicher Studien zur systemischen Chemotherapie, Hormontherapie und Immunmodulation bisher keine etablierte Therapie mit gesicherter Wirksamkeit.
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Eine besondere Herausforderung und Hoffnung liegt deshalb in der weiteren Erforschung der molekularen Pathogenese und entsprechender zielgerichteter Therapien, um auch Patienten in fortgeschrittenen Tumorstadien eine effiziente und verträgliche Behandlungsoption bieten zu können.
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Grundsätzlich sollten Patienten mit HCC in allen Stadien wegen der Komplexität der oft interdisziplinären Therapieentscheidungen in Zentren vorgestellt und möglichst in Studien behandelt werden.
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Prof. Dr. med. Wolfgang E. Fleig
Universitätsklinikum Leipzig AöR
Philipp-Rosenthal-Straße 27
04103 Leipzig
eMail: wolfgang.fleig@uniklinik-leipzig.de
