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DOI: 10.1055/s-2007-966708
© Georg Thieme Verlag KG Stuttgart · New York
In situ carcinoma of pancreas diagnosed by EUS-FNA
Publication History
Publication Date:
18 February 2008 (online)
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Endoscopic ultrasonography (EUS) is now a widely accepted modality for visualizing pancreatic lesions, and EUS-guided fine-needle aspiration (EUS-FNA) appears to be a safe and effective method for establishing the histological diagnosis of pancreatic tumors [1] [2] [3]. However, it is sometimes difficult to obtain samples from very small targets, especially tumors of 1 cm or less. We report a case in which EUS-FNA was useful for the diagnosis of in situ carcinoma of the pancreas. A 65-year-old patient was admitted to our hospital because of dilatation of the main duct in the pancreatic body as seen on transabdominal ultrasonography. Serum carcinoembryonic antigen and carbohydrate antigen 19 – 9 levels were within normal limits. Computed tomography and magnetic resonance cholangiopancreatography (MRCP) revealed mild dilatation of the main pancreatic duct ([Fig. 1]). During endoscopic retrograde pancreatography, deep cannulation proved impossible due to severe stricture of the pancreatic duct, and therefore no adequate sample of pancreatic juice could obtained. EUS showed an echogenic structure 3 mm in diameter and 5 mm in length in the stenotic duct of the pancreas ([Fig. 2]). EUS-FNA was performed for a histological diagnosis of the echogenic structure in the pancreatic duct. The cytological examination demonstrated clusters of atypical cells consistent with adenocarcinoma ([Fig. 3]). The histopathological examination of the pancreas achieved by pancreatic duodenectomy showed an intraductally spreading carcinoma that was 8 mm in maximum length, 3 mm in diameter, in the main duct of the pancreatic body. The histopathological diagnosis was in situ carcinoma of the pancreas ([Fig. 4] – [6]).
Fig. 1 Magnetic resonance cholangiopancreatography (MRCP) showing a stricture of the pancreatic duct and a dilatation of the distal duct.
Fig. 2 EUS showing an echogenic structure 3 mm in diameter in the pancreatic duct (inside white dashed outline). This lesion is consistent with the ductal stenosis observed by MRCP. MPD: main pancreatic duct.
Fig. 3 Cytology of the samples obtained by EUS-FNA. A cluster of atypical cells is evident (Papanicolaou’s stain, × 1250).
Fig. 4 Histopathological examination of surgical specimen reveals intraductally spreading carcinoma in the main duct of the pancreatic head. Red areas: inflammatory changes in the pancreas; arrows: pancreatic ducts (main and branch).
Fig. 5 Distribution of the carcinoma. Blue area: pancreas parenchyma; red areas: pancreatic ducts (main and branch); red circle: carcinoma in the main duct.
Fig. 6 Histopathological examination shows intraductally spreading carcinoma in the main duct of the pancreatic body (H & E, × 250).
Endoscopy_UCTN_Code_CCL_1AF_2AZ_3AB
References
- 1 Vilmann P, Jacobsen G K, Henriksen F W. et al . Endoscopic ultrasonography with guided fine needle aspiration biopsy in pancreatic disease. Gastrointest Endosc. 1992; 38 172-173
- 2 O’Toole D, Palazzo L, Arotçarena R. et al . Assessment of complication of EUS-guided fine-needle aspiration. Gastrointest Endosc. 2001; 53 470-474
- 3 Bhutani M S, Hawes R H, Baron P L. et al . Endoscopic ultrasound guided fine needle aspiration of malignant pancreatic lesions. Endoscopy. 1997; 29 854-858
M. Kitano, MD, PhD
Division of Gastroenterology and Hepatology
Department of Internal Medicine
Kinki University School of Medicine
377-2, Ohno-Higashi
Osaka-Sayama, 589-8511
Japan
Fax: +81-72-3672880
Email: kitano@med.kindai.ac.jp