Transmitterfunktionen in der menschlichen Epidermis am Beispiel keratinozytärer Glutamatrezeptoren[*]

Zusammenfassung

In der Epidermis des Menschen werden zunehmend Transmitter und Rezeptoren gefunden, die ursprünglich ausschließlich im Nervensystem vermutet wurden. Hierzu zählen unter anderem Glutamat-, Acetylcholin- und Purinrezeptoren. Die einzelnen Rezeptorfamilien beeinflussen dabei sowohl die Proliferation und Differenzierung des Keratinozyten als auch die Barrierefunktion der Epidermis. Am Beispiel keratinozytärer Glutamatrezeptoren werden Transmitterfunktionen in der Epidermis beschrieben, die ursprünglich exklusiv dem Nervensystem zugeschrieben wurden.

Abstract

Transmitters and receptors which were originally presumed to be located exclusively in the nervous system are increasingly being found in human epidermis. Among these are glutamate, acetylcoline and purin receptors. The individual receptor families influence the proliferation, differentiation of the keratinocytes as well as the barrier function of the epidermis. Using keratinocytic glutamate receptors, this article describes transmitter functions in the epidermis which were originally attributed solely to the nervous system.

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1 Vortrag beim wissenschaftlichen Jahres-Symposium der Berliner Stiftung für Dermatologie, 12. Mai 2007, Berlin.