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Planta Med 2007; 73(3): 292-295
DOI: 10.1055/s-2007-967108
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Evaluation of Antifungal and DNA-Damaging Activities of Alkaloids from Branches of Porcelia macrocarpa

João Henrique G. Lago1 , Mariana H. Chaves2 , Mariane Cruz C. Ayres2 , Débora G. Agripino3 , Maria Cláudia M. Young3
  • 1Centro de Ciências e Humanidades, Universidade Presbiteriana Mackenzie, São Paulo, SP, Brazil
  • 2Departamento de Química, Universidade Federal do Piauí, Teresina, PI, Brazil
  • 3Seção de Fisiologia e Bioquímica de Plantas, Instituto de Botânica, São Paulo, SP, Brazil
Further Information

Publication History

Received: July 17, 2006

Accepted: December 22, 2006

Publication Date:
12 March 2007 (online)

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Abstract

Bioactivity-guided fractionation of the alkaloidal fractions of the CH2Cl2 extract from branches of Porcelia macrocarpa using mutant yeast strains of Saccharomyces cerevisiae and fungi Cladosporium cladosporioides and C. sphaerospermum led to the isolation of bioactive alkaloids: two tetrahydrobenzylisoquinolines (1 and 2), two aporphines (3 and 4), one proaporphine (5), one oxoaporphine (6), four azantraquinones (7 - 10) and four azafluorenones (11 - 14). The alkaloids cleistopholine (7) and 6-methoxycleistopholine (8) showed the highest fungitoxic activity while the mixture of 6- and 7-methoxyonychine (12 + 13) and 6,7-dimethoxyonychine (14) showed a weak DNA-damaging potential.

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Prof. Dr. João Henrique G. Lago

Centro de Ciências e Humanidades

Universidade Presbiteriana Mackenzie

CEP 01302-907

São Paulo

SP

Brazil

Phone: +55-151-121-148-145

Email: joaolago@iq.usp.br