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Planta Med 2007; 73(4): 336-340
DOI: 10.1055/s-2007-967136
Original Paper
Pharmacology
© Georg Thieme Verlag KG Stuttgart · New York

Therapeutic Effect of Combined Triptolide and Glycyrrhizin Treatment on Rats with Collagen Induced Arthritis

Wandong Zhang1 , Cheng Lu1 , Zhenli Liu1 , Dajian Yang2 , Shilin Chen2 , Albert Cha2 , Zhipeng Wu3 , Aiping Lu1 , 2 , 3
  • 1Institute of Basic Theory, China Academy of Chinese Medical Sciences, Beijing 100700, P. R. China
  • 2Institute of Modern Chinese Medicine, The Hong Kong Polytechnic University, Shenzhen 518057, P. R. China
  • 3National Pharmaceutical Engineering Research Center, Jiangxi Province, Nanchang 330006, P. R. China
Further Information

Publication History

Received: December 4, 2006

Accepted: February 12, 2007

Publication Date:
12 March 2007 (online)

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Abstract

For investigating the effects of a combination therapy of triptolide (TP) with glycyrrhizin (GL) in rats with collagen-induced arthritis (CIA), the arthritic index was examined, and the levels of anti-CII IgG, TNF-α and IL-10 in serum were measured by ELISA. Our results showed that combined triptolide and glycyrrhizin treatment (TP 13.40 μg, GL 26.78 mg) can reduce the arthritic index of CIA rats and decrease the level of anti-CII IgG and TNF-α in serum. The observed effect was similar to the one measured upon application of TP 17.86 μg, GL 26.78 mg and TP 17.86 μg. The level of IL-10 was not significantly different among the rats of the TP 17.86 μg, of the TP 17.86 μg, GL 26.78 mg and of the TP 13.40 μg, GL 26.78 mg groups while the IL-10 levels in rats of the TP 13.40 μg and GL 26.78 mg groups were significantly higher. Combined triptolide 13.40 μg and glycyrrhizin 26.78 mg can therefore significantly inhibit collagen induced arthritis, and the effect was similar to the one of triptolide at 17.86 μg.

Key words

Triptolide - glycyrrhizin - combination therapy - collagen-induced arthritis

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Dr. Aiping Lu

Institute of Basic Theory

China Academy of Chinese Medical Sciences

Dongzhimen

Beijing 100700

People’s Republic of China

Phone: +86-10-6406-7611

Fax: +86-10-6401-3896

Email: lap64067611@126.com