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Planta Med 2007; 73(5): 496-498
DOI: 10.1055/s-2007-967165
Letter
Natural Product Chemistry
© Georg Thieme Verlag KG Stuttgart · New York

Tarennane and Tarennone, Two Novel Chalcone Constituents from Tarenna attenuata

Xian-Wen Yang1 , 2 , Jun-Song Wang1 , Yue-Hu Wang1 , Hai-Tao Xiao3 , Xu-Jia Hu1 , Shu-Zhen Mu1 , Yan-Lin Ma4 , Hua Lin4 , Hong-Ping He1 , Ling Li4 , Xiao-Jiang Hao1
  • 1State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People’s Republic of China
  • 2Department of Natural Product Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, People’s Republic of China
  • 3School of Pharmacy, Guiyang Medical College, Guiyang, People’s Republic of China
  • 4Yunnan Pharmacological Laboratories of Natural Products, Kunming Medical College, Kunming, People’s Republic of China
Further Information

Publication History

Received: December 6, 2006 Revised: January 15, 2007

Accepted: February 21, 2007

Publication Date:
04 April 2007 (online)

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Abstract

Two novel chalcone constituents, tarennane (1) and tarennone (2), together with nine known compounds, were isolated from the whole plant of Tarenna attenuata. By analysis of physical and spectroscopic data, the structures of new compounds were elucidated as (E)-4-[3-(4-hydroxy-3-methoxyphenyl)-acryl]-3,4,5-trimethoxycyclohexa-2,5-dienone (1) and 1,2-bis(3,5-dimethoxy-4-hydroxyphenyl)-3-hydroxypropan-1-one (2). These two compounds were tested for antioxidant activities in the MTT and DPPH assays. Compound 1 revealed potent antioxidant activities against H2O2-induced impairment in PC12 cells, but neither of them showed DPPH radical-scavenging activity with IC50 values of 181.1 and 210.3 μM, respectively.

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Prof. Dr. Xiao-Jiang Hao

Key Laboratory of Phytochemistry and Plant Resources in West China

Kunming Institute of Botany

Chinese Academy of Sciences

Kunming 650204

People’s Republic of China

Phone: +86-871-522-3263

Fax: +86-871-521-9684

Email: haoxj@mail.kib.ac.cn

    www.thieme-connect.de/ejournals/toc/plantamedica