Abstract
Different aldehydes and amines react with acyl cyanides in the presence of a catalytic amount of the Schreiner thiourea catalyst to give the corresponding N -acyl amino nitriles in high yields. The scope of the reaction is broad and both aromatic and aliphatic aldehydes and amines can readily be used.
Key words
acylcyanation - α-amino nitriles - multicomponent reactions - organocatalysis - acyl cyanides
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10 On mixing aldehyde, amine, catalyst, additive, and acetyl cyanide together at 0 °C, the product was obtained with poor yield due to considerable side product formation.
