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Semin Thromb Hemost 2007; 33(2): 123-127
DOI: 10.1055/s-2007-969023
Copyright © 2007 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Platelet-Leukocyte Interactions in Inflammation and Atherothrombosis

Andreas E. May1 , Harald Langer1 , Peter Seizer1 , Boris Bigalke1 , Stephan Lindemann1 , Meinrad Gawaz1
  • 1Medizinische Klinik III, Eberhard Karls Universität Tübingen, Tübingen, Germany
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Publication History

Publication Date:
06 March 2007 (online)

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ABSTRACT

Inflammatory processes at the vascular wall result in the development of atherosclerosis. Platelet interactions with leukocytes may play a key role in the initiation of inflammation. They trigger autocrine and paracrine activation processes, leading to leukocyte recruitment (in)to the vascular wall. This article highlights the molecular basis and the inflammatory pathways initiated by platelet-leukocyte interactions.

KEYWORDS

Platelets - inflammation - atherothrombosis - leukocytes - chemokines

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Andreas E MayM.D. 

Medizinische Klinik III, Eberhard Karls Universität Tübingen

Otfried-Müller-Straße 10, D-72076 Tübingen, Germany

Email: andreas.may@med.uni-tuebingen.de