Papaverine Biotransformation by Silene alba Cell Suspension

J. L. Verdeil; F. Bister-Miel; J. L. Guignard; C. Viel

doi:10.1055/s-2007-969051

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Planta Med 1986; 52(1): 1-3
DOI: 10.1055/s-2007-969051

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Papaverine Biotransformation by Silene alba Cell Suspension

J. L. Verdeil, F. Bister-Miel, J. L. Guignard, C. Viel

Faculty of Pharmacy of Paris-Sud, 3 rue J. B. Clément, F-92290 Châtenay-Malabry, France

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Publication History

1985

Publication Date:
26 February 2007 (online)

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Abstract

Silene alba cell suspensions were supplied with papaverine hydrochloride. Seven biotransformation compounds were obtained of which four were alkaloidal. The two most important compounds are regioselective demethylation products: 6-monodemethylpapaverine and 4′-monodemethylpapaverine.