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Planta Med 1986; 52(1): 64-65
DOI: 10.1055/s-2007-969074
Communications

© Georg Thieme Verlag Stuttgart · New York

Isolation and Hypoglycemic Activity of Coixans A, B and C, Glycans of Coix lachryma-jobi var. ma-yuen Seeds1

Michiko Takahashi, Chohachi Konno, Hirosh Hikino
  • Pharmaceutical Institute, Tohoku University, Aoba-yama, Sendai, Japan
1 Antidiabetes drugs, Part 16. Also Part 103 in the series on the validity of the Oriental medicines
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Publication History

1985

Publication Date:
26 February 2007 (online)

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Abstract

A water extract of the Oriental crude drug “yokui-nin” (coix seeds), Coix lachryma-jobi var, ma-yuen seeds, disclosed a marked hypoglycemic action when administered to mice. Fractionation of the extract, by monitoring the pharmacological activity, led to isolation of three glycans, coixans A, B and C. These components elicited remarkable hypoglycemic effects in normal and hyperglycemic mice treated with alloxan.