Effect of Oriental Plant Drugs on Platelet Aggregation II1. Effect of Qian-Hu Coumarins on Human Platelet Aggregation

T. Okuyama; C. Kawadi; S. Shibata; M. Hoson; T. Kawada; H. Osada; T. Noguchi

doi:10.1055/s-2007-969098

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Planta Med 1986; 52(2): 132-134
DOI: 10.1055/s-2007-969098

Full Papers

Effect of Oriental Plant Drugs on Platelet Aggregation II¹. Effect of Qian-Hu Coumarins on Human Platelet Aggregation

T. Okuyama² , C. Kawadi² , S. Shibata² , M. Hoson³ , T. Kawada³ , H. Osada³ , T. Noguchi³

²Department of Pharmacognosy and Phytochemistry, Meiji College of Pharmacy, Nozawa 1-35-23, Setagaya-ku, Tokyo, Japan
³The Third Department of Surgery, St. Marianna University School of Medicine, Sugao 2095, Miyamae-ku, Kawasaki-shi, Japan

1 Part I of this series: Hoson, M.; Kawada, T.; Osada, H.; Noguchi T.; Okuyama T.; Shibata, S (1985), Igaku no Ayumi, 132(8), 584

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Publication History

1985

Publication Date:
26 February 2007 (online)

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Abstract

Five kinds of furo- and pyrano-coumarins isolated from Chinese Drug “Qian-Hu”, the root of Peucedanum decursivum Maxim. (= Angelica decursiva Fr. et Sav.) and P. praeruptorum Dunn., and two kinds of furocoumarins isolated from Angelica edulis Miyabe were tested on their effects on human platelet aggregation induced by 2 µM ADP.

Nodakenin (1) and nodakenetin (2) were found to show the most inhibitory activity against both primary and secondary wave of aggregation induced by 2 µM ADP. Ae-II (= vaginidin) (3) and Ae-III (= isopeucenidin) (4) showed inhibition against only secondary wave aggregation. Pd-C-V (6) and Pd-Ia (7) were rather promotive in the primary wave aggregation. Pd-C-II (5) and dicoumarol (8) showed no activity.

Coumarin (9) and umbelliferone (10), a biosynthetic intermediate of Qian-Hu coumarins, showed also strong activity on primary and secondary platelet aggregation.