Isolation and Hypoglycemic Activity of Dioscorans A, B, C, D, E, and F; Glycans of Dioscorea japonica Rhizophors1

Hiroshi Hikino; Chohachi Konno; Michiko Takahashi; Miki Murakami; Yoshiaki Kato; Masami Karikura; Teruaki Hayashi

doi:10.1055/s-2007-969112

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Planta Med 1986; 52(3): 168-171
DOI: 10.1055/s-2007-969112

Full Papers

Isolation and Hypoglycemic Activity of Dioscorans A, B, C, D, E, and F; Glycans of Dioscorea japonica Rhizophors¹

Hiroshi Hikino² , Chohachi Konno² , Michiko Takahashi² , Miki Murakami² , Yoshiaki Kato³ , Masami Karikura³ , Teruaki Hayashi³

²Pharmaceutical Institute, Tohoku University, Aoba-yama, Sendai 980, Japan.
³Research Laboratory, Koshiro and Co., 1-10-13 Ina, Minoo, Osaka, Japan.

1 Antidiabetes drugs, Part. 21. Also Part 109 in the validity of the Oriental medicines.

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1985

Publikationsdatum:
26. Februar 2007 (online)

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Abstract

Aqueous methanol/water extracts of the Oriental crude drug “sanyaku”, Dioscorea japonica and D. batatas rhizophors, notably lowered blood glucose concentration in mice. Activity-guided fractionation of the extract from D. japonica afforded six glycans, dioscorans A, B, C, D, E, and F, which exhibited remarkable hypoglycemic effects in normal and alloxan-induced hyperglycemic mice.