Antiinflammatory Compounds from Plagiorhegma dubium Cell Culture¹

Abstract

Successive fractionation of a crude methanolic extract of cultured Plagiorhegma dubium cells, followed by assay of the biological activity using cobra venom factor induced paw oedema, led to the detection and isolation of three compounds with antiinflammatory activity. The substances were identified as the protoberberine alkaloid jatrorrhizine and the lignaneglucosides dehydrodiconiferyl-alcohol-4-β-D-glucoside and its isomer dehydrodiconiferyl-alcohol-γ-β-D-glucoside, the latter a compound not previously described in the literature.