Plant Anticancer Agents XXXVII. Constituents of Amanoa oblongifolia

Xinde Fang; N. P. Dhammika Nanayakkara; Charles H. Phoebe; John M. Pezzuto; A. Douglas Kinghorn; Norman R. Farnsworth

doi:10.1055/s-2007-969511

Planta Med 1985; 51(4): 346-347
DOI: 10.1055/s-2007-969511

Reports

Plant Anticancer Agents XXXVII. Constituents of Amanoa oblongifolia [1]

Xinde Fang² , N. P. Dhammika Nanayakkara³ , Charles H. Phoebe⁴ Jr. , John M. Pezzuto³ , A. Douglas Kinghorn³ , Norman R. Farnsworth³

²A Visiting Scholar in the World Health Organization Collaborating Centre for Traditional Medicine, College of Pharmacy, University of Illinois at Chicago, on leave from the Shanghai College of Traditional Chinese Medicine, Shanghai, People's Republic of China
³Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Health Sciences Center, University of Illinois at Chicago, Chicago, Illinois 60612, U.S.A.
⁴Life Sciences Laboratory, Water's Associates, Milford, Massachusetts 07157, U.S.A.

Abstract

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Abstract

4′-Demethyldeoxypodophyllotoxin was isolated as the sole cytotoxic constituent of a chloroform-soluble extract of the stem bark of Amanoa oblongifolia. Also identified from this extract were a number of noncytotoxic isolates that comprised the lignans, (+)-sesamin and paulownin, the triterpenes, friedelin, canophyllol, betulin, betulinic acid, and ursolic acid, and the sterols, β-sitosterol and daucosterol.

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References

1 For the previous paper in this series, see reference 1