Acetoxychavicol Acetate, an Antifungal Component of Alpinia galanga ¹

Abstract

The essential oils from fresh and dried rhizomes of Alpinia galanga showed an antimicrobial activity against gram-positive bacteria, a yeast and some dermatophytes, using the agar overlay technique. The main components of the oils were also tested and terpinen-4-ol was found most active. An n-pentane/diethyl ether extract of dried rhizomes was active against Trichophyton mentagrophytes. 1′-Acetoxychavicol acetate, 1′-acetoxyeugenol acetate and 1′-hydroxychavicol acetate identified by MS and NMR were found in the antifungally active fractions obtained by LSC. Acetoxychavicol acetate was active against the seven fungi tested and its MIC value for dermatophytes ranged from 50 to 250 µg/ml. Dried sliced rhizomes contained 1.5% of this compound. The compound was not found in rhizomes of Alpinia officinarum, Zingiber officinale and Kaempferia galanga.