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Planta Med 1984; 50(1): 47-52
DOI: 10.1055/s-2007-969619
Research Articles

© Georg Thieme Verlag Stuttgart · New York

Ein Oxepan-Derivat des Panaxadiols aus den Blättern von Panax notoginseng

An oxepane derivative of panaxadiol from the leaves of Panax notoginsengWei Junxiang1 , Chang Liangyu1 , Wang Jufen1 , Chen Wei-shin1 , Edmund Friedrichs2 , Heinrich Puff2 , Eberhard Breitmaier2
  • 1Yunnan Institute of Materia Medica, Academica Sinica, Kunming Yunnan, VR China
  • 2Institut für Organische Chemie und Biochemie der Universität Bonn, Gerhard-Domagk-Str. 1, D-5300 Bonn 1
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Publication Date:
26 February 2007 (online)

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Abstract

Hydrolysis of the crude saponin isolated from the leaves of Panax notoginseng (Burk.) F. H. Chen yields five sapogenins which are separated by column chromatography. The structures of four of those were elucidated earlier to be panaxadiol, panaxatriol, dammar-20(22)en-3β, 12β,26-triol and 20(R)-dammaran-3β, 12β,20,25-tetrol. The fifth sapogenin is identified as an oxepane derivative probably arising from acid catalyzed dehydration and rearrangement of panaxadiol. The structure as proposed from NMR data was confirmed by single-crystal X-ray diffractometry.