An Approach to the Antiinflammatory Activity of Borjatriol

A. Villar; R. Salom; M. J. Alcaraz

doi:10.1055/s-2007-969630

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Planta Med 1984; 50(1): 90-92
DOI: 10.1055/s-2007-969630

Research Articles

An Approach to the Antiinflammatory Activity of Borjatriol

A. Villar, R. Salom, M. J. Alcaraz

Departamento de Farmacognosia y Farmacodinamia, Facultad de Farmacia, Valencia, Spain

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Publication Date:
26 February 2007 (online)

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Abstract

The antiinflammatory activity of borjatriol (a diterpenoid isolated from Sideritis mugronensis Borja) was tested using the cotton pellet-granuloma assay. The compound inhibited the granuloma weight and the serum lysozyme activity in a dose-dependently way. The determination of this enzyme has allowed us to distinguish between an irritant (carrageenan) which reduces the granuloma weight and antiinflammatory substances (phenylbutazone and borjatriol).