Isolement et Détermination de Structure de l'Afrocurarine

M. Caprasse; L. Angenot; D. Tavernier; M. J. O. Anteunis

doi:10.1055/s-2007-969650

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Planta Med 1984; 50(2): 131-133
DOI: 10.1055/s-2007-969650

Research Articles

Isolement et Détermination de Structure de l'Afrocurarine

The isolation and structure elucidation of AfrocurarineM. Caprasse¹ , L. Angenot¹ , D. Tavernier² , M. J. O. Anteunis²

¹Laboratoire de Pharmacognosie, Institut de Pharmacie, Université de Liège, rue Fusch, 5, B-4000 Liége
²Department of Organic Chemistry, NMR Spectroscopic Unit, Rijks-universiteit Gent, Krijgslaan, 281 (S4bis) B-9000 Gent, Belgium

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Publication History

Publication Date:
26 February 2007 (online)

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Abstract

The structure and the stereochemistry of afrocurarine (a new unsymmetrical bisindole alkaloid) previously isolated from s. usambarensis Gilg. are established especially from ¹H-NMR spectroscopic data.

The separation of quaternary alkaloids has always been very tedious. Ion-pair reversed-phase column chromatography applied to the purification of afrocurarine is proved very useful and seems to be a suitable technique in quaternary alkaloid research.