Antihepatotoxic Actions of Lignoids from Schizandra chinensis Fruits

Hiroshi Hikino; Yoshinobu Kiso; Heihachiro Taguchi; Yukinobu Ikeya

doi:10.1055/s-2007-969681

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Planta Med 1984; 50(3): 213-218
DOI: 10.1055/s-2007-969681

Research Articles

Antihepatotoxic Actions of Lignoids from Schizandra chinensis Fruits[1]

Hiroshi Hikino² , Yoshinobu Kiso² , Heihachiro Taguchi³ , Yukinobu Ikeya³

²Pharmaceutical Institute, Tohoku University, Aoba-yama, Sendai, Japan
³Tsumura Laboratory, Komae, Tokyo, Japan

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Publikationsdatum:
26. Februar 2007 (online)

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Abstract

The antihepatotoxic effects of twenty-three lignans, twenty-two from the fruits of Schizandra chinensis and one from the fruits of Kadsura japonica, were investigated utilizing carbon tetrachloride (CCl₄)- and galactosamine (GalN)-induced cytotoxicity in primary cultured rat hepatocytes as model systems. Prominent protective actions were found with wuweizisu C and schisantherin D in CCl₄-treated cultures, and deoxygomisin A, gomisin N, wuweizisu C, gomisin C and schisantherin D were effective in preventing GalN-induced cell damage. Structure-activity relationship suggests that the methylenedioxy group of the dibenzocyclooctane skeleton may play an important role in antihepatotoxic activity.

1 Part 11 in the Tohoku University series on Liver-protective drugs. Also Part 60 on the validity of the Oriental medicines.