Tertiary Indole Alkaloids from Fruits of Tabernaemontana dichotoma

Premila Perera; Finn Sandberg; Teris A. van Beek; Robert Verpoorte

doi:10.1055/s-2007-969691

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Planta Med 1984; 50(3): 251-253
DOI: 10.1055/s-2007-969691

Research Articles

Tertiary Indole Alkaloids from Fruits of Tabernaemontana dichotoma

Premila Perera¹ , Finn Sandberg¹ , Teris A. van Beek² , Robert Verpoorte²

¹Department of Pharmacognosy, Biomedical Centre, University of Uppsala, Uppsala, Sweden
²Department of Pharmacognosy, Gorlaeus Laboratories, State University of Leiden, The Netherlands

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Publication Date:
26 February 2007 (online)

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Abstract

The crude acetic acid extract of Tabernaemontana dichotoma fruits showed convulsive and spasmolytic activity. From the chloroform soluble fraction of this extract, eleven indole alkaloids were isolated and identified as (-)-apparicine, coronaridine, 3-ketopropylcoronaridine, dichomine, 19R-epiheyneanine, isomethuenine, 12 methoxy-voaphylline, voaphylline, vobasine, vallesamine and O-acetyl-vallesamine.