Alkaloids from Roots of Strempeliopsis strempelioides - Structures of Strempeliopine and Strempeliopidine[1]

Abstract

From the roots of Strempeliopsis strempelioides K. Schum. (Apocynaceae), the following alkaloids were isolated: (+)-pleiocarpamine, (-)-aspidospermine, (+)-eburnamonine, (+)-tubotaiwine, (+)-haplocidine, (-)-vallesamidine, (+)-tubotaiwine N-oxide, (-)-strempeliopine (1a) and a bisindolic base (+)-strempeliopidine (2). Another bisindole alkaloid of composition C₃₈H₄₆N₄ was isolated in minute quantity. The structures were established on the basis of spectral and chemical evidence.

1 Part XCVII in the series Plant Substances; Part XCVI: see ref. (1). This work represents a part of the Thesis of A. Laguna, Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences 1980. Presented at the “29. Vortragstagung der Gesellschaft für Arzneipflanzenforschung” in Marburg/Lahn, 9.-13. June 1981, see Planta Medica 42, 135 (1981).

1 Part XCVII in the series Plant Substances; Part XCVI: see ref. (1). This work represents a part of the Thesis of A. Laguna, Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences 1980. Presented at the “29. Vortragstagung der Gesellschaft für Arzneipflanzenforschung” in Marburg/Lahn, 9.-13. June 1981, see Planta Medica 42, 135 (1981).