Effects of Stilbene Components of Roots of Polygonum ssp. on Liver Injury in Peroxidized Oil-fed Rats

Yoshiyuki Kimura; Hiroji Ohminami; Hiromichi Okuda; Kimiye Baba; Mitsugi Kozawa; Shigeru Arichi

doi:10.1055/s-2007-969810

Planta Medica, Inhaltsverzeichnis

Planta Med 1983; 49(9): 51-54
DOI: 10.1055/s-2007-969810

Research Articles

Effects of Stilbene Components of Roots of Polygonum ssp. on Liver Injury in Peroxidized Oil-fed Rats

Yoshiyuki Kimura¹ , Hiroji Ohminami¹ , Hiromichi Okuda¹ , Kimiye Baba² , Mitsugi Kozawa² , Shigeru Arichi³

¹2nd Department of Medical Biochemistry, School of Medicine, Ehime University, Ehime, Japan
²Osaka College of Pharmacy, Osaka, Japan
³The Research Institute of Oriental Medicine, Kinki University, Osaka, Japan

Abstract

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Abstract

The effects of Polygonum cuspidatum SIEB. et Zucc. (“Kojo-kon” or “Itadori-kon” in Japanese) of Polygonum multiflorum (“Kashuwu” or “Tsurudo-kudami-kon” in Japanese) roots and their stilbene components (piceid and 2,3,5,4′-tetrahydroxy stilbene-2-O-D-glucoside) on liver injury caused in rats by feeding peroxidized oil were investigated. Piceid and 2,3,5,4′-tetrahydroxy stilbene-2-O-D-glucoside were found to partly inhibit the deposition of lipid peroxides in the liver of those rats. The stilbene glucosides reduced the elevation of GOT and GPT levels in the serum of the rats. Furthermore, resveratrol, piceid and 2,3,5,4′-tetrahydroxy stilbene-2-O-D-glucoside were found to inhibit lipid peroxidation induced by ADP and NADPH in rat liver microsomes.

Key Word Index

Polygonum cuspidatum - Polygonum multiflorum - Polygonaceae - Stilbene - Liver Injury - Lipid Peroxide

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