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Planta Med 1983; 49(9): 51-54
DOI: 10.1055/s-2007-969810
Research Articles

© Hippokrates Verlag Stuttgart

Effects of Stilbene Components of Roots of Polygonum ssp. on Liver Injury in Peroxidized Oil-fed Rats

Yoshiyuki Kimura1 , Hiroji Ohminami1 , Hiromichi Okuda1 , Kimiye Baba2 , Mitsugi Kozawa2 , Shigeru Arichi3
  • 12nd Department of Medical Biochemistry, School of Medicine, Ehime University, Ehime, Japan
  • 2Osaka College of Pharmacy, Osaka, Japan
  • 3The Research Institute of Oriental Medicine, Kinki University, Osaka, Japan
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Publication History

1983

1983

Publication Date:
26 March 2007 (online)

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Abstract

The effects of Polygonum cuspidatum SIEB. et Zucc. (“Kojo-kon” or “Itadori-kon” in Japanese) of Polygonum multiflorum (“Kashuwu” or “Tsurudo-kudami-kon” in Japanese) roots and their stilbene components (piceid and 2,3,5,4′-tetrahydroxy stilbene-2-O-D-glucoside) on liver injury caused in rats by feeding peroxidized oil were investigated. Piceid and 2,3,5,4′-tetrahydroxy stilbene-2-O-D-glucoside were found to partly inhibit the deposition of lipid peroxides in the liver of those rats. The stilbene glucosides reduced the elevation of GOT and GPT levels in the serum of the rats. Furthermore, resveratrol, piceid and 2,3,5,4′-tetrahydroxy stilbene-2-O-D-glucoside were found to inhibit lipid peroxidation induced by ADP and NADPH in rat liver microsomes.

Key Word Index

Polygonum cuspidatum - Polygonum multiflorum - Polygonaceae - Stilbene - Liver Injury - Lipid Peroxide