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Planta Med 1983; 49(12): 199-203
DOI: 10.1055/s-2007-969850
Research Articles

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Skin Irritant and Tumor Promoting Diterpene Esters of the Tigliane Type from the Chinese Tallow Tree (Sapium sebiferum)*

E. H. Seip, H. H. Ott, E. Hecker
  • Deutsches Krebsforschungszentrum, Institut für Biochemie, Federal Republic of Germany
* Part of this work was presented at: Erster Gesamtkongress der Pharmazeutischen Wissenschaften - Fortschritte in der Arzneimittelforschung, Munich, April 17-20, 1983, book of abstracts, p. 215.
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Publication History

1983

Publication Date:
26 March 2007 (online)

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Abstract

From seed oil of the Chinese tallow tree skin irritant principles could be enriched; their diterpene parent was recognized as 12-deoxyphorbol(1a). Skin irritant Sapium factors S1 to S8 were isolated from roots; they represent 13-monoesters of 12-deoxyphorbol (1a) (S4-S8), 12,13-diesters of phorbol (2a) (S1 and S2) and of 6β,7β-epoxyphorbol (3a) (S3). The factors S1, S5 and a homologue of S3 are known as tumor promoters.

Key Word Index

Sapium sebiferum - Euphorbiaceae - Diterpene esters - Phorbol derivatives - Skin irritants - Tumor promoters