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Planta Med 1983; 49(12): 252-254
DOI: 10.1055/s-2007-969864
Research Articles

© Hippokrates Verlag Stuttgart

Effects of Hippadine, an Amaryllidaceae Alkaloid, on Testicular Function in Rats*

S. Chattopadhyay1 , U. Chattopadhyay1 , P. P. Mathur1 , K. S. Saini2 , S. Ghosal2
  • 1Hormone Research Unit, Department of Physiology, Institute of Medical Sciences
  • 2Department of Pharmaceutics, Banaras Hindu University, Varanasi, India
* Part 4 in the series: “Chemical Constituents of Amaryllidaceae”. For Part 3 see ref. [1].
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Publication History

1983

1983

Publication Date:
26 March 2007 (online)

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Abstract

Hippadine, an alkaloid of the Amaryllidaceae, produced reversible inhibition of fertility in male rats. A decrease in the testicular weight and DNA content and an increase in protein concentration indicated a fall in the relative proportion of freshly divided cells. The weights of accessory sex organs revealed continued production of androgens. A plausible mechanism for this biochemical function of hippadine is envisaged.

Key Word Index

Hippadine - Crinum species - Amaryllidaceae - 4,5-Etheno-8,9-methylenedioxy-6-phenanthridone - Alkaloids - Testicular function - Spermatocytogenesis - Antifertility agent