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DOI: 10.1055/s-2007-969873
© Hippokrates Verlag Stuttgart
Biological Standardisation of Zanthoxylum Roots for Antisickling Activity
Publication History
1982
1982
Publication Date:
26 March 2007 (online)
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Abstract
Antisickling activity reported in the aqueous extracts of Zanthoxylum xanthoxyloides (LAM.) WATERMAN (= Fagara xanthoxyloides AM.) root has been demonstrated in roots of other species of Zanthoxylum. Z. gilletii (DE WILD.) WATERMAN (= Fagara macrophylla ENGL.) showed a much higher sickling reversal potency than Z. xanthoxyloides. The unit of antisickling activity has been defined and a procedure is described for estimation of the potency of sickling reversal activity (p-hydroxy benzoic acid equivalent) in antisickling agents whether synthetic or natural in origin.
Key Word Index
Zanthoxylum xanthoxyloides - Sickle cell anaemia - Sickling reversal standardisation