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Planta Med 1983; 48(6): 120-123
DOI: 10.1055/s-2007-969903
Research Articles

© Hippokrates Verlag Stuttgart

Nachweis sedativ-hypnotischer Wirkstoffe im Hopfen

4. Mitteilung1: Die Pharmakologie des Hopfeninhaltsstoffes 2-Methyl-3-buten-2-olThe Sedativ-hypnotic Principle of Hops4. Communication: Pharmacology of 2-Methyl-3-buten-2-olR. Wohlfart2 3 , R. Hänsel3 , H. Schmidt4
  • 3Institut für Pharmakognosie und Phytochemie der Freien Universität Berlin
  • 4Zyma GmbH, München
1 3. Mitteilung: HÄNSEL, R., R. WOHLFART und H. SCHMIDT: Planta Med. 45, 224 (1982).2 Teilergebnisse der Dissertation von R. WOHLFART.
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1982

1982

Publication Date:
26 March 2007 (online)

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Abstract

The central nervous system depressant activity of 2-Methyl-3-buten-2-ol was studied by motility tests in order to clarify if it contributes to the sedative action of hops, a folklore medicine used in Europe. 2-Me-thyl-3-buten-2-ol administered to wistar-rats caused a decline of motility by 50% when given i.p. at a dose of 206.5 mg/kg.

The onset of activity occures within two minutes reaching a miximum response within two hours.

The results obtained by the “Chimney-Test” [11] lead to the conclusion that the decrease in motility following the administration of 2-Methyl-3-buten-2-ol cannot be ascribed to a muscle relaxing effect. The effectiveness of 2-Methyl-3-buten-2-ol was compared with that of the sedative drug Methylpentynol in Open Field-Tests. Both substances, which are closely related chemically, were effective within the same dose range.

Key Word Index

Humulus lupulus - Cannabaceae - Hypnotic principle of hops - Pharmacology of 2-Methyl-3-buten-2-ol