RSS-Feed abonnieren
DOI: 10.1055/s-2007-969903
© Hippokrates Verlag Stuttgart
Nachweis sedativ-hypnotischer Wirkstoffe im Hopfen
4. Mitteilung1: Die Pharmakologie des Hopfeninhaltsstoffes 2-Methyl-3-buten-2-olThe Sedativ-hypnotic Principle of Hops4. Communication: Pharmacology of 2-Methyl-3-buten-2-ol 1 3. Mitteilung: HÄNSEL, R., R. WOHLFART und H. SCHMIDT: Planta Med. 45, 224 (1982).2 Teilergebnisse der Dissertation von R. WOHLFART.Publikationsverlauf
1982
1982
Publikationsdatum:
26. März 2007 (online)
![](https://www.thieme-connect.de/media/plantamedica/198306/lookinside/thumbnails/10.1055-s-2007-969903-1.jpg)
Abstract
The central nervous system depressant activity of 2-Methyl-3-buten-2-ol was studied by motility tests in order to clarify if it contributes to the sedative action of hops, a folklore medicine used in Europe. 2-Me-thyl-3-buten-2-ol administered to wistar-rats caused a decline of motility by 50% when given i.p. at a dose of 206.5 mg/kg.
The onset of activity occures within two minutes reaching a miximum response within two hours.
The results obtained by the “Chimney-Test” [11] lead to the conclusion that the decrease in motility following the administration of 2-Methyl-3-buten-2-ol cannot be ascribed to a muscle relaxing effect. The effectiveness of 2-Methyl-3-buten-2-ol was compared with that of the sedative drug Methylpentynol in Open Field-Tests. Both substances, which are closely related chemically, were effective within the same dose range.
Key Word Index
Humulus lupulus - Cannabaceae - Hypnotic principle of hops - Pharmacology of 2-Methyl-3-buten-2-ol